摘要
目的探讨人脑星形细胞瘤中细胞外基质金属蛋白酶诱导因子(EMMPRIN)和基质金属蛋白酶-9(MMP-9)的表达,以及它们在星形细胞瘤侵袭性生长中的作用。方法采用免疫组织化学S-P法对49例星形细胞瘤、11例脑膜瘤和7例正常人脑组织中的EMMPRIN和MMP-9的表达进行检测。结果EMMPRIN和MMP-9的表达在Ⅲ-Ⅳ级星形细胞瘤显著高于Ⅰ-Ⅱ级星形细胞瘤(P<0.01),在Ⅰ-Ⅱ级星形细胞瘤又显著高于脑膜瘤(P<0.01),在脑膜瘤高于正常脑组织(P<0.05)。且EMMPRIN和MMP-9的表达呈显著正相关(r=0.378,P<0.01)。结论EMMPRIN和MMP-9表达均是反映人脑星形细胞瘤侵袭和预后的重要标记物,它们可能相互影响和共同调节星形细胞瘤的侵袭性生长。
Objective To investigate the expressions and significance of extracellular matrix metalloproteinase inducer （EMMP RIN） and matrix metalloproteinase-9（MMP-9） in human brain astrocytoma. Method The expressions of EMMPRIN and MMP-9 were detected by immunohistochemistrical technique （S-P） in 49 specimens of astrocytomas, 11 specimens of meningomas and 7 specimens of normal human brain tissues. Results The expressions of EMMPRIN and MMP-9 were significant higher in the astrocytomas of grade Ⅲ-Ⅳ than those in the astrocytomas of grades Ⅰ-Ⅱ （P〈0.01）, in which the expressions of EMMPRIN and MMP-9 were significant higher than those in the meningomas, in which the expressions of EMMPRIN and MMP-9 were significant higher than those in the normal human brain tissues （P〈0.01）. There was a significantly positive correlation （r=-0.378, P〈0.01） between the expressions of EMMP RIN and MMP-9. Conclusion The expressions of EMMPRIN and MMP-9 are important biological markers reflecting the invasiveness and prognosis of human brain astrocytoma. They may exert mutual effects and co-regulate the invasive growth of human brain astrocytoma.
出处
《中国临床神经外科杂志》
2006年第3期143-145,共3页
Chinese Journal of Clinical Neurosurgery
关键词
人脑星形细胞瘤
脑膜瘤
EMMPRIN
MMP-9
免疫组化
Human brain astrocytoma
Meningoma
Extracellular, matrix metalloproteinase inducer
Matrix metalloproteinase 9
Immunohistochemistry
