摘要
目的提出一种基于生存分析统计技术的结核病患者治疗依从性的评价方法。方法将退出疗程作为所关心的结局事件,将从登记治疗开始到退出疗程的时间作为坚持治疗时间,利用生存分析统计技术估计坚持治疗率和中位坚持治疗时间以评价结核病患者的治疗依从性。结果将本文所提方法应用于重庆市某区结核病患者治疗管理数据的结果显示:所提方法可以对包括未完成疗程患者在内的结核病患者的治疗依从性进行评价,并同时调整治疗失败、迁出、死亡对评价结果的影响。初治患者5月末的坚持治疗率为0.7406,复治患者7月末的坚持治疗率接近0。初、复治患者的中位坚持治疗时间分别为1.97个月和1.03个月。结论本文所提方法是一种更合理的结核病患者治疗依从性的评价方法,对现行的结核病管理工作具有实际意义。
Purpose To propose a method of evaluation of treatment adherence for patients with tuberculosis. Methods By defining defaulting as a failure event and time from treatment starting to defaulting as survival time, we applied survival analysis technique with a real data to estimate a so called adherent rate and a median adherent time for evaluation of treatment adherence for patients with tuberculosis. Results Estimation using this method included both in-course and treatment completed patients, and treatment failure, transferring out and death cases was also taken into account. The adherent rate was 0. 7406 by the end of the fifth month and near zero by the end of the seventh month for new and re-treat patients, respectively. The median adherent time for the new and re-treat patients were 1.97 months and 1.03 months, respectively. Conclusions Comparing to the traditional patient adherence evaluation, this method is more reasonable and has more practical meaning for actual TB patients administration.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2006年第2期269-272,278,共5页
Fudan University Journal of Medical Sciences
基金
世界银行贷款/英国赠款中国结核病控制项目之重庆结核病控制项目(中疾控结办发03-32)
关键词
结核病
治疗依从性
评价
生存分析
tuberculosis
treatment adherence
evaluation
survival analysis
