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Grape seed proanthocyanidin extract induced mitochondria-associated apoptosis in human acute myeloid leukaemia 14.3D10 cells 被引量：14

Grape seed proanthocyanidin extract induced mitochondria-associated apoptosis in human acute myeloid leukaemia 14.3D10 cells
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摘要 The important aim in cancer treatment is the selective killing of cancer cells without damaging healthy cells and the most commonly used chemotherapy for eliminating cancer is achieved by activating the mitochondrial apoptotic pathway. Therefore, identification of new agents that can selectively kill cancer cells becomes crucial in cancer clinical treatment. The important aim in cancer treatment is the selective killing of cancer cells without damaging healthy cells and the most commonly used chemotherapy for eliminating cancer is achieved by activating the mitochondrial apoptotic pathway. Therefore, identification of new agents that can selectively kill cancer cells becomes crucial in cancer clinical treatment.
作者 HU Hong QIN Yi-min
机构地区 Pulmonary and Critical Care Medicine Department of Pulmonary Medicine
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2006年第5期417-421,共5页 中华医学杂志（英文版）
基金 This study was supported by a grant from NIH (No. CA14599).
关键词 grape seed proanthocyanidin extract mitochondrial membrane potential APOPTOSIS caspases activation acute myeloid leukaemia cells grape seed proanthocyanidin extract mitochondrial membrane potential apoptosis caspases activation acute myeloid leukaemia cells
分类号 R733.7 [医药卫生—肿瘤]
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参考文献11

  • 1X. Ye,R.L. Krohn,W. Liu,S.S. Joshi,C.A. Kuszynski,T.R. McGinn,M. Bagchi,H.G. Preuss,S.J. Stohs,D. Bagchi.The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells[J].Molecular and Cellular Biochemistry (-).1999(1-2)
  • 2Bagchi D,Garg A,Krohn RL,Bagchi DJ,Balmoori J,Stohs SJ.Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophageactivation in mice[].General Pharmacology.1998
  • 3Johnstone RW,Ruefli AA,Lowe SW.Apoptosis: a link between cancer genetics and chemotherapy[].Cell.2002
  • 4Bagchi D,Bagchi M,Stohs S,Das DK,Ray SD,Kuszynsky CA,et al.Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention[].Toxicology.2000
  • 5Zhao J,Wang J,Chen Y,Agarwal R.Anti-tumor- promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3’-gallate as the most effective antioxidant constituent[].Carcinogenesis.1999
  • 6Agarwal C,Singh RP,Agarwal R.Grape seed extract induced apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release[].Carcinogenesis.2002
  • 7Igney FH,Krammer PH.Death and anti-death: tumor resistance to apoptosis[].Nature Reviews Cancer.2002
  • 8Baumann MA,Paul CC.The AML14 and AML14.3D10 cell lines: a long-overdue model for the study of eosinophils and more[].Stem Cells.1998
  • 9Dong JM,Zhao SG,Huang GY,Liu Q.NADPH oxidase-mediated generation of reactive oxygen species is critically required for survival of undiffetentiated human promyelocytic leukemia cell line HL-60[].Free Radical Research.2004
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同被引文献80

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二级引证文献81

Chinese Medical Journal
2006年 第5期

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