摘要
目的研究多发性骨髓瘤(MM)患者13号染色体长臂特定位点的缺失及与临床表现、预后的关系。方法采用荧光原位杂交技术检测68例MM患者骨髓标本中Rb-1基因和13q14.3位点的缺失,结合临床资料作统计分析。结果13号染色体部分缺失的总检出率为51%(35/68),其中Rb-1基因缺失43%(29/68),13q14.3位点缺失为52%(23/44),两位点同时缺失者66%(29/44)。卡方检验分析显示13号染色体部分缺失与患者起病时多种临床特征及早期疗效、1年生存率有关。结论Rb-1基因和13q14.3位点的缺失在MM中均较为常见,13号染色体部分缺失对MM的生物学行为有一定影响。
Objective To explore the specific locus deletion of the long arm of chromosome 13 and its relationship with the clinical behavior and prognosis of multiple myeloma （MM）. Methods FISH analysis was performed on bone marrow smears from 68 patients with MM to study the deletion of Rb-1 gene and locus 13q14.3 on chromosome 13. The statistic value of its effect on clinical features were determined. Results 35 out of the 68（51% ） cases were found with deletion of chromosome 13;deletion of Rb-1 gene were found in 29 （43%） cases; deletion of locus 13q14.3 were found in 23 out of 44 （ 52% ） cases; the analysis results were same in 66% of the cases（29/44） with the above two probes. Chi-square test showed that partial deletion of chromosome 13 was associated with clinical behavior, early chemotherapy response and 1 year survival. Conclusion Deletion of Rb-1 gene and locus 13q14. 3 were both common cytogenetic changes in MM patients with effect on the biological behavior of the disease.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2006年第3期217-220,共4页
Chinese Journal of Internal Medicine
