摘要
Protein post-translational modification plays an important role in organism. It makes the protein obtain more complicated structures, perfect functions, more accurate regulations and more spe-cific operations. The most common protein post- translational modifications include ubiquitylation, phosphorylation, glycosylation, lipodation, methyla-tion, and acetylation and so on. Ubiquitylation plays an essential role in cellular functions such as cellular differentiation, apoptosis, DNA repair, antigen proc-essing, and stress response. Phosphorylation is re-lated to physiological and pathological processes including cellular signal conduction, nervous activity, muscle contraction and proliferation, development and differentiation of cells. Protein glycosylation is of great importance for many cell processes like im-munoprotection, virus replication, cell growth, and occurrence of inflammation and so on. Lipodation is vital to signal conduction. Histone methylation and acetylation are responsible for transcription regula-tion. In vivo, different post-translational modifications do not occur isolatedly, but influence each other’s function and cooperate with each other. Under-standing what influences the post-translational modi-fications will help to uncover cellular processes and protein network in molecular level and finally direct more precise drug design targeting molecules. Post-translational modification mimics are set to dominate the next wave of protein therapeutics and become powerful medicinal tools in the 21st century.
Protein post-translational modification plays an important role in organism. It makes the protein obtain more complicated structures, perfect functions, more accurate regulations and more specific operations. The most common protein posttranslational modifications include ubiquitylation, phosphorylation, glycosylation, lipodation, methylation, and acetylation and so on, Ubiquitylation plays an essential role in cellular functions such as cellular differentiation, apoptosis, DNA repair, antigen proc- essing, and stress response. Phosphorylation is related to physiological and pathological processes including cellular signal conduction, nervous activity, muscle contraction and proliferation, development and differentiation of cells. Protein glycosylation is of great importance for many cell processes like immunoprotection, virus replication, cell growth, and occurrence of inflammation and so on. Lipodation is vital to signal conduction. Histone methylation and acetylation are responsible for transcription regulation. In vivo, different post-translational modifications do not occur isolatedly, but influence each other＇s function and cooperate with each other. Understanding what influences the post-translational modifications will help to uncover cellular processes and protein network in molecular level and finally direct more precise drug design targeting molecules. Post-translational modification mimics are set to dominate the next wave of protein therapeutics and become powerful medicinal tools in the 21 st century.
关键词
蛋白质
磷酸化
糖基化
甲基化
乙酰化作用
研究进展
protein post-translational modification, ubiquitylation,phosphorylation, glycosylation, lipodation, methylation, acetylation.
