摘要
目的探讨长期应用托吡酯(TPM)对幼年大鼠空间学习记忆能力的影响。方法以生后28天的海藻酸(KA)致痫大鼠为模型,经TPM治疗8周,观察动物癫痫行为;经Morris水迷宫对大鼠的空间学习记忆能力及对已存储信息的再摄取能力进行评价。结果KA致痫后经TPM治疗组大鼠出现自发性反复惊厥(SRS)次数(3.50±3.84)较未经TPM治疗组次数(7.36±3.75)明显减少(t=2.33,P<0.05)。该组动物仅在水迷宫测试第一天找到平台的潜伏期(590.6±230.9)秒较未经治疗组(422.6±122.3)秒明显延长(t=2.11,P<0.05),但此后3天两组潜伏期则无差异。TPM对未经KA致痫的大鼠水迷宫操作无影响,间歇三天后在相同测试条件下各组潜伏期均无差异。结论TPM对发育期大脑的长期记忆功能及信息再摄取能力均无影响,而且对幼鼠的空间学习能力的影响也是极短暂的。
Objective： To investigate the chronic effect of topiramate on spatial learning and memory to young rats. Methods： P28 KA-indueed rats were used. After 8-week treatment of topiramate, spontaneous recurrent seizureswere recorded; Spatial learning and memory ability was evaluated by Morris water maze. Results： TPM-treated ratshad significantly fewer （ 3.50±3.84 ） spontaneous recurrent seizures than rats without TPM treatment （ 7.36±3.75 ）. On the first day of Morris water maze, they also had statistically longer latency to the platform （590. 6±230. 9 s）than those from the group without TPM treatment （422. 6 ±122. 3 s）, but no latency differences were found in the following three days. TPM had no effect on water maze performance to rats without KA induction. After three days of interval, no differences were found in all groups under the same experimental situation. Conclusion： For developing ratbrain, TPM has no impairment on the ability of long-term memory and information retrieval meanwhile its negativeeffect on spatial learning is temporary.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2006年第3期150-152,共3页
Chinese Mental Health Journal
关键词
托吡酯
癫痫
动物研究
海藻酸
学习
记忆
topiramate
epilepsy
animal study
kainate acid
learning
memory
