摘要
目的观察18FDGPET/CT在术前检测食管癌淋巴结转移及分期的临床应用价值。方法随机选择拟行手术治疗的食管癌病人30例,术前1周内行18FDGPET/CT检查,12例病人同期行CT增强扫描,术前均不接受放化疗,根据术后病理对比PET/CT与CT诊断食管癌淋巴结转移及确定淋巴结分期的价值。结果22例存在淋巴结转移,共切取并分离淋巴结243枚,转移淋巴结49枚。PET/CT诊断淋巴结转移的敏感性、特异性、准确性分别为93·9%、91·2%、91·8%,CT分别为40·8%、96·9%、85·6%;PET/CT阳性与阴性预测值分别为73·0%,98·3%,CT为76·9%,86·6%。PET/CT确定淋巴结分期的敏感性、特异性、准确性分别为95·5%、62·5%、86·7%,CT分别为72·7%、75·0%、73·3%。结论18FDGPET/CT图像融合技术诊断食管癌淋巴结转移及确定淋巴结分期临床应用价值优于CT。
Objective To evaluate the clinical value of ^18FDG PET/Cr in the diagnosis of lymph node metastasis and evaluation of node staging for esophageal earcinoma. Methods A prospective study was performed to access whether ^18F FDG PET/CT can improve the diagnostic accuracy in lymph node metastasis for patients with esophageal carcinoma, 30 patients underwent esaphagectomy with extensive dissection of lymph nodes. PET/CT findings were compared with that of CT. Results The pathological examination cenfinned metastasis in 22 patients and 49 out of 243 excised lymph nodes. In PET/cr analysis, the sensitivity in the detectice of lymph node metastasis was 93.9%, specificity was 91.2%, with a diagtostic accuracy of 91.8%. The positive and negative predictive value was 73.0% and 98.3%, respectively. CT resultod in a sensitivity of 40.8%, specificity of 96.9%, accuracy of 85.6%, the PPV was 76.9% and NPV 86.6%, respectively. The difference of sensitivity （ P 〈 0.001 ）, accuracy （ P =0.032） and negative predictive value （ P 〈 0.001） between the two radiologlcal modalities was statistically significant.Conclusion With a high sensitivity and accuracy in the diagnosis of lymph node metastasis, PET/CT appears necessary in preoperative examinations on detectice of lymph node metastasis for esophageal carcinoma.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2006年第1期28-31,共4页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
食管肿瘤
淋巴转移
肿瘤分期
氟脱氧葡萄糖F1
体层摄影术
发射型计算机
图像处理
计算机辅助
Esophageal neoplasms Lymphatic metastasis Neoplasm staging Fludeoxyglucose F 18 Tomography, emission-computed ted Image processing, computer-assisted
