摘要
目的合成奥美拉唑中间体2-巯基-5-甲氧基-1H-苯并咪唑。方法以4-甲氧基-2-硝基苯胺为原料,经锌粉还原后,再与乙基黄原酸钾环缩合制得2-巯基-5-甲氧基-1H-苯并咪唑。结果收率80%。结论该方法简单易行,适合工业化生产。
2-mercapto-5-methoxybenzimidazole,a key intermediate for the synthesis of omeperazole, was synthesized in 80% yield over two steps. Commercially available 2-nitro-4-methoxyaniline was used as starting material and converted via reduction with zinc dust and cyclization with potassium ethyl xanthate into the title compound, suggesting that this procedure is suitable for industrial production.
出处
《广东药学院学报》
CAS
2006年第1期39-40,共2页
Academic Journal of Guangdong College of Pharmacy
