摘要
目的 建立头孢克肟缓释片释放度测定方法，评价其体外释药行为。方法 用紫外分光光度法和释放度试验，考察头孢克肟缓释片在不同释放介质中不同释放时间的累积释放度。结果 头孢克肟在288nm处有最大吸收，在1．5—37．5μg／mL范围内与吸收度呈良好的线性关系：A=0．0457p-0．0037，r=0．9999。头孢克肟缓释片在水、胃、肠液中1—16h的体外释药行为理想，符合零级方程释药模型。结论 本法简便、快速，适用于头孢克肟缓释片的质量控制。
Objective To investigate in vivo drug release behaviors of cefixime sustained-release tablets. Methods Ultraviolet spectrophotometry and release test were applied to determine the release of cefixime in cefixime sustained-release tablets under different media and time points. Results Cefixime had the highest absorption peak at 288 nm and a good linearity within the range of 1.5 - 37.5μg/ml （A =0. 0457C- 0. 0037, r = 0. 9999 ）. The release behavior of cefixime sustained -release tablets in water, artificial gastric juice and artificial intestinal juice could be best described by a zero-order drug release pattern over 16 h in in vitro release studies. Conclusion This method is simple, quick and can be used for quality control of cefixime sustained-release tablets.
出处
《广东药学院学报》
CAS
2006年第1期16-18,共3页
Academic Journal of Guangdong College of Pharmacy
关键词
头孢克肟缓释片
释放度
紫外分光光度法
cefixime sustained-release tablets
in vitro release
ultraviolet spectrophotometry
