摘要
目的探讨幽门螺杆菌(Hp)感染及谷胱甘肽转硫酶P1(GSTP1)基因型多态性表达与反流性食管炎(RE)的关系。方法RE患者119例和正常对照者121例,以快速尿素酶试验及13C-尿素呼气试验检测Hp感染,通过PCR-RFLP方法检测GSTP1基因型。结果具有GSTP1突变型基因表达、Hp感染阴性者RE发病率显著增加(P<0.05)。RE患者中GSTP1野生纯合子型基因组Hp感染率显著高于突变型基因组(P<0.05)。结论GSTP1基因型多态性与RE发病风险相关,RE患者GSTP1基因表达与Hp易感性相关。
Objective To study the relationships of Helicobacter pylori （Hp）, genetic polymorphisms of glutathione stransferase P1 （GSTP1） and reflux esophagitis （RE）. Methods 119 patients with RE and 121 controls were enrolled for this study. Rapid urease test and ^13C-rapid urea breath test （^13C-UBT） were used to check Hp. PCR-based restriction fragment length polymorphisms（PCR-RFLP） was used to detect GSTP1 genotype. Results The risk of RE would notably increase in the GSTP1 valiant gene （GM and MM） group without Hp （P 〈0.05）. In RE group, the rate of Hp infection of GSTP1 wild homozygote group （GG） was notably higher than that of GM and MM group （ P 〈 0.05 ）. Conclusion GSTP1 was correlated with RE. In RE group, the GSTP1 gene was associated with susceptibility to the infection of Hp.
出处
《中国医刊》
CAS
2006年第3期32-33,共2页
Chinese Journal of Medicine
关键词
幽门螺杆菌
谷胱甘肽转硫酶P1基因
反流性食管炎
Helicobacter pylori（Hp）
Glutathione s-transferase P1 gene （GSTP1）
Reflux esophagitis（ RE ）
