摘要
神经纤毛蛋白-1（Neuropilin-1）最早是作为轴突导向分子collapsin／semaphorin的受体被发现，在神经发育过程中引导轴突选择正确途径以成功到达靶区，与此同时又可作为血管内皮生长因子受体-2（VEGFR-2）的共受体表达于血管内皮细胞，在血管新生中发挥作用。近来的研究表明NRP-1可通过依赖于VEGF和独立于VEGF的方式参与调节肿瘤血管新生，在肿瘤生长转移中发挥作用。
Neuropilin-1 （NRP-1） was first described as a coreceptor implicated in neuronal guidance that bound members of the semaphorin/collapsin family and guide correct location of axon in neural development. NRP-1 is also expressed in endothelial cells and is believed to promote angiogenesis by acting as a coreceptor with vascular endothelial growth factor （VEGF） receptor 2. Recent studies suggest that NRP-1 can function through both a VEGF-dependent and VEGF-independent fashion in tumor angiogenesis, growth and metastasis.
出处
《世界肿瘤杂志》
2005年第4期307-309,共3页
Tumour Journal of the World
基金
湖北省科技攻关基金（2003AA301C05）
