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脂氧素A4抑制结缔组织生长因子诱导的系膜细胞产生单核细胞趋化蛋白1 被引量：3

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摘要 脂氧素A4（LXA4）具有拮抗多种炎症介质、生长因子的作用，被称为炎症反应“刹车信号。结缔组织生长因子（CTGF）参与多种细胞的增殖、迁移和黏附，在肾脏纤维化的发病机制中占据重要地位。我们尚未检索到CTGF对趋化因子合成的调节作用及LXA4对CTGF作用的调节报道。我们检测CTGF对肾小球系膜细胞合成单核细胞趋化蛋白-1（MCP-1）的调节作用，并测定LXA4对CTGF作用的调节，探讨这些作用的细胞内信号转导机制，报告如下。
作者 吴升华 陆超 董玲 周国平 姜新猷
机构地区 南京医科大学第一附属医院儿科
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2006年第3期180-182,共3页 Chinese Journal of Nephrology
基金 江苏省135医学重点人才工程基金(2002-45)
关键词 单核细胞趋化蛋白1 结缔组织生长因子 系膜细胞合成 脂氧素A4 胞内信号转导机制 CTGF LXA4 肾脏纤维化 调节作 炎症介质
分类号 R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献8

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二级参考文献23

  • 1吴升华,陆超,董玲,姜新猷.脂氧素A4通过上调Smac表达诱导肾间质成纤维细胞凋亡[J].中华肾脏病杂志,2004,20(5):339-342. 被引量：7
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共引文献9

同被引文献37

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  • 2盛红.小儿急性肾炎患者IL-2、IL-6、TNF水平的变化[J].放射免疫学杂志,2005,18(3):188-189. 被引量：2
  • 3吴升华,陆超,董玲,姜新猷.蛋白酪氨酸磷酸酶2/核因子-κB途径介导脂氧素A4拮抗系膜细胞白介素6的合成[J].中华肾脏病杂志,2005,21(7):413-416. 被引量：4
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  • 8Fischer DB, Christman JW, Badr KF. Fifteen-S- hydroxyeicosatetraenoic acid (15- S - HETE ) specifically antagonizes the chemotactic action and glomerular synthesis of leukotriene B4 in the rat. Kidney Int, 1992, 41: 1155- 1160.
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中华肾脏病杂志
2006年 第3期

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