摘要
甲状腺相关眼病是一种器官特异性自身免疫性疾病,确切的发病机制尚不清楚。近年来研究表明CD40和其配体CD40ligand(CD40L)与自身免疫性疾病的发病关系密切。CD40-CD40L作为一种重要的共刺激信号,通过诱导细胞活化和细胞因子的产生,调节细胞、体液免疫并参与介导细胞内信号转导。本文就CD40-CD40L的结构和分布、对免疫反应的调节及其在甲状腺相关眼病发病中的作用作一综述。
Thyroid associated ophthalmopathy is an organ special autoimmune disorder, of which the pathogenesis is still undear. Recent researchs have showed CD40-CD40L interaction may play an important role in this autoimmune disorder. As an important costimulatory molecule, CD40 and CD40 ligand,regulate the cell and humoral immunity and transfer intracellar signal through activating cells and cytokines production. We reviewed the structure and expression of CD40 and its ligand, focusing on the function of CD40-CD40L in regulating immune responses of thyroid associated ophthalmopathy.
出处
《国际眼科杂志》
CAS
2006年第1期183-187,共5页
International Eye Science
基金
中国福建省自然科学基金(No.C0510018)
