摘要
目的 探讨B超引导下穿刺腹膜恶性间皮瘤的组织形态及细胞学特点。方法 对19例腹膜恶性间皮瘤穿刺标本进行病理组织形态学、细胞学、组织化学及免疫组化观察。结果 本组男性12例，女性7例，年龄34～76岁，平均58．1岁。19例穿刺标本组织学证实为10例腺管乳头状型、3例未分化型、1例印戒细胞型、1例小细胞型、2例低度恶性囊状细胞型和2例纤维母细胞型。细胞学涂片16例呈阳性，3例呈阴性。肿瘤细胞对Keratin、Vimentin、EMA及抗间皮细胞抗原均呈阳性表达。19例CI染色均有不同程度阳性改变，而对HCI染色则呈阴性。结论 结合临床表现，对B超引导下穿刺标本进行组织病理学、细胞学、组织化学及免疫组化等观察能够准确诊断腹膜恶性间皮瘤。
Objective To study histological and cytological characteristics of malignant mesothelioma of the peritoneum by needle biopsy. Methods Needle biopsy specimens of 19 cases of malignant mesothelioma of the peritoneum were studied with pathological, cytological, histochemical and immunohistochemical staining examination. Results of 19 cases, 12 were males and 7 were females, with a mean age of 58. 1 years. Histopathlogical examination of needle biopsy specimens revealed that 10 of them were tubulopapillary. 3 undifferentiated. 1 signet ringoid cell, 1 small cell, 2 of low-grade malignant cystic cell and 2 of myofibroblastic cell types. 16 cases were positive by cytology smear but 3 negative. Immunohistochemical staining showed that the neoplastic cells of all cases were positive for keratin, vimentin, EMA, antimesothelial cell antigen and CI but negative for HCI. Conclusion The diagnosis of malignant mesothelioma of the peritoneum can be established by its clinical manifestation, combined with pathological, cytological, histochemical staining and immunohisitochemical staining of specimens obtained by ultrasound guided needle biopsy.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2006年第3期260-261,共2页
Medical Journal of Chinese People's Liberation Army
关键词
恶性间皮瘤
组织形态学
细胞学
组织化学
免疫组织化学
malignant mesothelioma
histomorphology
cytology
histochemistry
immunohistochemistry
