摘要
目的:探讨细胞增殖抗原标记物(Ki67)和血管内皮生长因子(VEGF)与喉鳞状细胞癌预后的关系。方法:用免疫组织化学方法研究Ki67和VEGF在32例喉鳞状细胞癌组织中的表达,其中术后3年局部复发5例(复发组),转移3例(转移组),死亡8例(死亡组),生存24例(生存组)。结果:死亡组Ki67和VEGF的表达均明显高于生存组(均P<0.01)。Ki67在复发组和转移组中高表达,均高于未复发组和未转移组(均P<0.01)。VEGF在复发组中亦高表达,高于未复发组(P<0.05)。Cox多因素回归分析发现,Ki67(危险比为3.236,P<0.01)、喉癌的T分期(危险比为1.382,P<0.05)和术前淋巴结转移情况(危险比为0.316,P<0.05)是影响喉鳞状细胞癌预后的独立指标。结论:Ki67和VEGF与喉鳞状细胞癌的预后有关,两指标的高表达预示着喉癌较差的预后,有助于喉癌治疗方案的制定。
Objective：To investigate the prognostic value of Ki67 and VEGF in squamous cell carcinoma of larynx. Method：The expressions of Ki67 and VEGF in squamous cell carcinoma of larynx tissues of 32 follow-up cases were studied by immunohistochemical staining, of which five cases recurred（recurrent group）, three cases metastasized（metastatic group）, eight case died（deceased group） and 24 cased survived（survival group） in three years after operations. Result：The expressions of Ki67 and VEGF in deceased group were higher than those in survival group（ P〈0.01）. Overexpression of Ki67 could be found in recurrent group and in metastatic group（ P〈0.01）. And VEGF expressed higher in recurrent group than in nonrecurrent group（ P〈0.05）. On Cox regression of multivariate analysis, Ki67（RR： 3.236, P〈0.01）, clinical T stage（RR： 1.382, P〈0.05） and metastasis of lymph nodes（RR：0.316, P 〈0.05） were shown to be independent prognostic factors for survival of squamous cell carcinoma of larynx. Conclusion：Ki67 and VEGF were related to the prognosis of squamous cell carcinoma of larynx, overexpression of the two markers indicated poor prognosis of the disease, and they might be helpful for the treatment of carcinoma of larynx.
出处
《临床耳鼻咽喉科杂志》
CAS
CSCD
北大核心
2006年第6期246-248,共3页
Journal of Clinical Otorhinolaryngology
基金
国家杰出青年科学基金(No:39925035)
教育部高等学校骨干教师基金(No:2000)
高等学校博士学科点专项科研基金(No:2002)
