摘要
目的了解产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌耐药谱的变化,为临床用药提供依据。方法用法国BioMerieux公司的VITEK-60全自动细菌鉴定仪鉴定细菌。采用K-B单片琼脂扩散法做药敏试验；用WHONET5．0分析软件对产ESBLs肺炎克雷伯菌的药敏结果进行统计。结果检出624株肺炎克雷伯菌,其中产ESBILs 269株,占43．1％。药敏结果显示除哌拉西林外,18种抗生素对不产ESBLs肺炎克雷伯菌有较高的抗菌活性。产ESBLs肺炎克雷伯菌的耐药率均明显高于不产ESBLs菌。结论本院检出的肺炎克雷伯菌产ESBLs株可能是头孢菌素型(CTX-M型)和SHV型酶介导。ESBLs尚未得到有效控制。3年间产ESBLs肺炎克雷伯菌耐药谱变化不大,亚胺培南、美洛培南对产ESBLs株耐药率最低。
Objective To understand the drug - resistant status of K pneumuniae producing extended - spectrum β- lactamase （ESBLs） and provide scientific basis for treatment of inl＇ection. Methods The bacteria were identified by automatic analytical apparatus VTTEK- 60 made by Biomerieux company in France. The Drug sensitivity test was carried out by Kirby - Bauer （K- B） method and the results were analyzed using WHONET5.0 software. Results Among the 524 strains of K pnettmoniae, 43.1% （269 strains）of them producing ESBLs. There were 18 antibiotics effective to K pneumoniae not producing ESBLs. The drug resistant rate of K pneumoniae producing ESBLs was higher that that not producing ESBLs. Conclusion The K pneumoniae producing ESBLs isolated is mainly mediated by enzymatically sensitive type of cephalospofin （ CTX - M type） and SHV type. The drug resistant spectrum of K pnettmuniae changes little in the last three years and the resistant rates of K pneumuniae producing ESBLs to imipenem, meropenem are the lowest.
出处
《中国热带医学》
CAS
2006年第3期503-504,共2页
China Tropical Medicine
关键词
超广谱Β-内酰胺酶
肺炎克雷伯菌
耐药性
Extended- spectrum β- lactamase （ESBLs）
K pneumuniae
Drug resistance
