摘要
目的采用慢性应激复制抑郁大鼠模型,观测抑郁模型大鼠蓝斑酪氨酸羟化酶的表达,探讨抑郁症的发病机制。方法将大鼠随机分为正常组、模型组,运用慢性轻度不可预见性应激配合孤养复制抑郁模型,以免疫组化方法研究抑郁模型大鼠海马蓝斑酪氨酸羟化酶的表达。结果与正常大鼠比较,模型组蓝斑酪氨酸羟化酶的表达下调,其平均灰度值分别为(62.16±2.43)和(89.00±1.83)(P<0.05)。结论抑郁模型大鼠蓝斑酪氨酸羟化酶的表达较正常大鼠显著减少。
Objective To study the mechanism of depression by investigating the expressional differences of tyrosine hydroxylase in locus coeruleus of depression model rats. Methods Rats were randomly divided into two groups： control group, depression model group. The depression model was replicated by chronic unpredictable mild stress and single house in 21 days. Tyrosine hydroxylase expression in locus coeruleus was investigated with immunohistochemistry technique. Results Compared to control group 89.00± 1.83, the average gray value of tyrosine hydroxylase in locus coeruleus were increased in depression model group 62. 16 ± 2.43 （ P 〈 0.05 ）. Conclusions The expression of tyrosine hydroxylase in locus eoeruleus of depression model rats has decreased.
出处
《中国行为医学科学》
CSCD
2006年第3期226-228,共3页
Chinese Journal of Behavioral Medical Science
基金
国家"十五"科技攻关项目资助课题(2001BA701A22)
关键词
抑郁症
蓝斑
酪氨酸羟化酶
Depression
Locus coeruleus
Tyrosine hydroxylase
