摘要
本文根据Svennerholm和蒋谷人等的方法略加改良,测定了蚌埠地区113例正常人,71例恶性肿瘤患者和82例非肿瘤疾病患者血清脂质结合唾液酸(LSA)的含量。正常值为12.4mg/dl(SD=±3.6mg/dl),71例不同肿瘤患者的平均值为28.2mg/dl(SD=±9.7mg/dl),阳性率为88.7％,82例非肿瘤疾病患者的平均值为16.82mg/dl(SD=±5.4mg/dl),假阳性率为17％。方法的灵敏度,重复性(平均CV=3.6％)和回收率(平均回收率=101.4％)测定结果是满意的。本研究的初步结果表明,血清LSA测定对肺癌、白血病、胃癌和食管癌具有一定的临床诊断价值。
Serum Lipid-Bound Sialic Acid (LSA) levels were determined in 113 healthy, 71 patients with malignant and 82 patients with non-tumorous diseases in Bengbu area according to modified Svennerholm's and Jiang Gurengs' methods. The normal level of serum LSA was 12.5mg/dl ( SD=±3.56mg/dl ) , the serum ISA levels in patients with malignant and in patients with non-tumorous diseases were 28.2mg/dl ( SD= ±9.7mg/dl ) and 16.8mg/dl ( SD = ±5.4 mg/dl ) respectively. The positive rate in malignant tumors was 88.7%, the false positive rate in non-tumorous diseases was 17%. The sensitivity, reproducibility and recovery associated with the assay turned out to be satisfactory. The preliminary results in our studies have proved that the determination of serum LSA is a Useful index in the diagnosis of lung cancer, leukcmia, carcinoma of the stomach and carcinoma of the esophagus.
出处
《蚌埠医学院学报》
CAS
1990年第2期75-78,共4页
Journal of Bengbu Medical College
关键词
恶性肿瘤
血清
LSA
诊断
测定
癌
serum 1ipid-bound sialic acid ( LSA )
total sialic acid ( TSA )
malignant
diagnosis
