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骨髓增生异常综合征发病机制的研究进展 被引量：15

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摘要 骨髓增生异常综合征(MDS)是源于骨髓造血干/祖细胞的恶性克隆性疾病。MDS的发生发展过程中,包含了骨髓细胞的凋亡、增殖及克隆扩张等多重机制。不同克隆的产生,可能与控制细胞凋亡或生长分化的基因有关。肿瘤坏死因子-α、Fas抗原以及增殖的T细胞克隆参与了MDS的发病机制。MDS向白血病的转化与p15INK4b基因的高度甲基化有关。
作者 胡晓梅 唐旭东 麻柔 羊裔明
机构地区 中国中医科学院西苑医院血液科 四川大学华西医院血液科
出处 《国际输血及血液学杂志》 CAS 2006年第2期132-136,共5页 International Journal of Blood Transfusion and Hematology
关键词 骨髓增生异常综合征 凋亡 增殖 克隆 发病机制
分类号 R551.3 [医药卫生—血液循环系统疾病] R735.102 [医药卫生—肿瘤]
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国际输血及血液学杂志
2006年 第2期

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