摘要
目的探讨纳米粒子是否能从体内排出。方法将纳米活性炭(ACNP)或印度墨水经静脉注入动物体内,在注射后不同时间收取胆汁和尿液,在透射电镜下观察有无纳米粒子的排出。在停药后不同时间取动物肝脏、肠和肾脏等脏器组织进行光镜病理检查,提供纳米粒子是否可以从这些器官排出的佐证。结果经静脉注射的纳米粒子可随血液分布到肝脏、肠和肾脏等脏器组织中,胆汁及尿液中含有大量高密度粒子。结论纳米粒子可能随胆汁,尿液排出体外;肺,小肠,大肠可能是纳米粒子排泄的另外途径。
OBJECTIVE To explore, the possible excretion pathways of nano-particles.METHODS Biliary and urinary samples were collected and prepared for transmission electron microscopy observation after activated carbon nano-particles （ACNP） and Indian ink （Ⅱ） were injected into rabit＇s vein. Meanwhile,liver, intestine and kidney were taken out and pathological sections were prepared for light microscopy observation.RESUTS The intravenous nano-partieles had wide distribution in animalis-liver, intestine and kidney and there were many nano-particles in bile and urine. CONCLUSION Nano-particales may be excreted through bile and urine. Lung, small intestine and large intestine may also be excretion pathways.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2006年第5期363-367,共5页
Chinese Pharmaceutical Journal
基金
国家自然科学基金资助项目(90406024-7)
军队十五科研基金重点(01Z024)
关键词
纳米粒子
纳米活性炭
印度墨水
nano-particles
active carbon nanoparticles
India ink
