摘要
目的研究妊娠期肝内胆汁淤积症(ICP)发病时胆酸对母体和胎儿的影响机制。方法以妊娠绵羊为对象,通过给妊娠绵羊安装颈静脉血管瘘并经该静脉多次大剂量灌注胆酸盐。结果胆酸灌注后实验组母羊有明显的瘙痒症状,并出现宫内窘迫及胎儿死亡,得到与ICP孕妇相似的结果。结论胆酸对母体和胎儿产生了作用,提示胆酸是导致ICP出现各种症状的重要因素。
Objective To investigate the effects of sodium cholate on the mother and fetuse in intrahepatic cholestasis of pregnancy （ICP）. Method Pregnant ewes were served as animal models. High dose of sodium cholate was infused to pregnant ewes through jugular fistula. Results The pruritus, fetal distress, and intrauterine death appeared in the animal of treated group, which were similar with the symptoms of pregnancy women in ICP. Conclusion The sodium cholate could influence on the mother and fetuse of the ewes ,and further confirmed sodium cholate was an important factor to induce symptoms of ICP.
出处
《实验动物与比较医学》
CAS
2006年第1期10-15,共6页
Laboratory Animal and Comparative Medicine
基金
国家自然科学基金资助项目(30471250)
关键词
妊娠期肝内胆汁淤积症
静脉灌注
胆酸盐
母羊
胎儿
Intrahepatic cholestasis of pregnancy
Intravenous infusion
Sodium cholate
Ewe
Fetus
