氯诺昔康对食管癌切除术病人围术期自然杀伤细胞及淋巴细胞亚群的影响被引量：8

导出

摘要氯诺昔康是新型非甾体类消炎镇痛药，通过抑制环氧化酶（COX）的活性，减少前列腺素的合成及激活神经内啡肽系统，从而产生镇痛作用，而且对肿瘤的发生、发展、转移也有抑制作用。但氯诺昔康对细胞免疫功能的影响尚不清楚。本研究通过比较围术期使用氯诺昔康和芬太尼的食管癌切除术病人外周血淋巴细胞表面分子、自然杀伤（NK）细胞的变化，研究氯诺昔康对细胞免疫功能的影响。

作者谭武菊牛新环李刚傅志俭孙巧梅

机构地区山东省立医院麻醉科

出处《中华麻醉学杂志》 CAS CSCD 北大核心 2006年第1期84-85,共2页 Chinese Journal of Anesthesiology

关键词淋巴细胞亚群自然杀伤细胞食管癌切除术氯诺昔康围术期病人非甾体类消炎镇痛药细胞免疫功能细胞表面分子外周血淋巴

分类号 R614 [医药卫生—麻醉学]

引文网络
相关文献

参考文献9

1Amano H,Hayashi I,Endo H,et al.Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth.J Exp Med,2003,197:221-232.
2Liu XH,Kirschenbaum A,Lu M,et al.Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line.J Biol Chem,2002,277:50081-50086.
3Gridelli C,Maione P,Airoma G,et al.Selective cyclooxygenase-2inhibitors and non-small cell lung cancer.Curr Med Chem,2002,9:1851-1858.
4Bishop-Bailey D,Calatayud S,Warner TD,et al.Prostaglandins and the regulation of tumor growth.J Environ Pathol Toxicol Oncol,2002,21:93-101.
5Koki AT,Khan NK,Woemer BM,et al.Characterization of cyclooxygenase-2 (COX-2) during tumorigenesis in human epithelial cancers:evidence for potential clinical utility of COX-2 inhibitors in epithelial cancers.Prostaglandins Leukot Essent Fatty Acids,2002,66:13-18.
6Trampitsch E,Pipam W,Moertl M,et a l.Preemptive randomized,double-blind study with lornoxicam in gynecological surgery.Schmerz,2003,17:4-10.
7Rosenow DE,Albrechtsen M,Stolke D.A comparison of patientcontrolled analgesia with lornoxicam versus morphine in patients undergoing lumbar disk surgery.Anesth Analg,1998,86:1045-1050.
8陈真福,吴善苏,谢治己,陈启忠,魏秀吾,钟进财,上官明化.三种不同浓度的氯诺昔康和吗啡用于静脉镇痛的比较[J].临床麻醉学杂志,2004,20(12):713-715. 被引量：5
9Rocca B,Spain LM,Ciabattoni G,et al.Differential expression and regulation of cyclooxygenase isozymes in thymic stromal cells.J Immunol,1999,162:4589-4597.

二级参考文献13

1McCormack K. The spinal actions of nonsteroidalanti-infammatory drugs and the dissociation between their antiinfammatory and analgesic effects. Drugs, 1994,47 (Suppl 5) : 28-45.
2Hitzenberger G, Radhoger-Welte S, Takacs F, et al.Pharmacokinetics of lornoxicam in man. Postgrad Med J,1990,66(Suppl 4) :22-27.
3Kullich W, Klein G. Influence of the nonsteroidal antiinflammatory drug lornoxicam iv on the secretion of the endogenous opiate peptides dynorphin and endorphin.Aktuel Rheumatol, 1992,17:128-132.
4Rosenow DE ,Albrechtsen M,Stolke D. A comparison of patient-controlled analgesia with lornoxicam versus morphine in patients undergoing lumbar disk surgery.Anesth Analg, 1998,86:1045-1050.
5Norholt SE, Sindet-Pedersen S, Larsen U, et al. Pain control after dental surgery: a double blind, randomised trial of lornoxicam versus morphine. Pain, 1996, 67:335-343.
6Berg J,Christoph T,Widerna M,et al. Isoenzyme-specific cyclooxygenaseinhibitors:a whole cell assay system using the human erythroleukemic cell line HEL and the human monocytic cell line Mono Mac 6.J Pharmacol Toxicol Methods,1997,37:179-186.
7李封元,张成栓.曲马多的不良反应概述[J].药物流行病学杂志,1997,6(2):89-90. 被引量：10
8佘守章,索琨,刘继云,苏健.静脉或硬膜外吗啡PCA药效学和血药浓度变化的临床研究[J].临床麻醉学杂志,1999,15(5):263-265. 被引量：55
9郑艳彬,李雪宁.非甾体抗炎药氯诺昔康[J].国外医药（合成药．生化药．制剂分册）,2001,22(3):166-169. 被引量：84
10龚志毅,叶铁虎,秦晓涛,于广祥,郭向阳,罗爱伦.氯诺昔康,吗啡和曲马多用于妇科开腹手术后患者自控镇痛的比较[J].中国医学科学院学报,2001,23(5):472-475. 被引量：36