摘要
目的研究用于防治母儿血型不合的抗溶冲剂的用药安全性问题。方法对抗溶冲剂进行了小鼠急性毒性试验,经预试实验无法测出其小鼠灌胃给药的LD50,故进行了小鼠灌胃该药,无明显毒性反应,最大耐受量的测定;应用Wistar大鼠对抗溶冲剂进行了致畸敏感期毒性实验。结果①小鼠灌胃给药最大耐受量为492g生药kg,相当于人临床用量的240倍,无明显毒性反应;②该药对大鼠生殖能力、胎鼠生长发育(外观、内脏、骨骼)均无不良影响。结论抗溶冲剂毒性很低,未发现胚胎毒性和致畸性,可用于孕期。
Objective To observe the safety of Kangrongehongji on preventing the disorder of ineompatable blood group between mother and fetus. Methods 20 mice , half male and half female, were fed three times eontinusly with Kangrongehongji solution after 12 hour＇ s fast. Each feeding interval was five hours and the dosage was 0.4 mg/10 g.The fur color, weitght,appetite,bowel movement, activity mental state were observed after seven days feeding.＇？. Wstar pregnant rata were randomly divied into nomal group, small dosage Kangrongehongji group, great dosage Kangrongehongji group and Vitamin AD group. Each pregnant rat was fed in the seventh day of pregnant and fed for ten days continuusly. In the ninteen day of pregnant, the whole pregnant rats were killed. The amount of fetus rat, the apperenee, skeleton and viscera of the fetus rats were observed. Results The fur color, weitght, appetite, bowel movement, activity mental state were normal and no dead experimental mouee was observed. Compared with normal group, there were no significant difference of fetus rata in the small and great dosage Kangrongchongji groups in length, body weitht and plaenta weight（ P 〉 0.05）.There were no malformal fetus rat in Kangrongchongji group and the skeleton was normal in the whole groups. Condusions Kangrongehongji has low toxicity without malfromation effeetion.
出处
《河北中医》
2006年第2期142-143,共2页
Hebei Journal of Traditional Chinese Medicine
基金
河北省中医药管理局资助项目
(编号96014)
