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甲苯二异氰酸酯对小鼠骨髓细胞的影响 被引量：1

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作者 季宇彬 郎朗 蒋晖
机构地区 哈尔滨商业大学生命科学与环境科学研究发展中心
出处 《毒理学杂志》 CAS CSCD 北大核心 2006年第1期38-39,共2页 Journal of Toxicology
基金 国家自然科学基金资助项目(30271108)
关键词 甲苯二异氰酸酯 激光共聚集 DNA RNA 染色体畸变 姐妹染色单体交换
分类号 R994.6 [医药卫生—毒理学]
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  • 1Kim SH, Choi GS, Ye YM, et al. Toluene diisoeyanate (TDI) regulates haem oxygenase - 1/ferritin expression:implications for toluene diisocyanate - induced asthma [J]. Clin Exp Immunol, 2010,160(3) : 489-497.
  • 2Littorin M, Axmon A, Broberg K, et al. Eye and airway symptoms in low occupational exposure to toluene Diisocyanate[ J]. Scand J Work Environ Health, 2007,33 (4) :280-285.
  • 3Timchalk C, Smith FA, Bartels MJ. Route dependent comparative metabolism of [ lgc ] toluene 2,4-diisocyanate and [ 14C ] toluene 2,4-diamine in Fischer 344 rats [ J ]. Toxicol Appl Pharmacol, 1994,124 : 181-190.
  • 4Lindberg HK, Korpi A, Santonen T, et al. Micronuelei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4- methylenediphenyl diisocyanate (MDI) [ J]. Mutat Res, 2011, 723(1) : 1-10.
  • 5Mishra PK, Panwar H, Bhargava A, et al. Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes [ J ]. J Biochem Mol Toxicol, 2008, 22(6) :429-440.
  • 6Marczynski B, Merget R, Teschner B,et al. Changes in low molecular weight DNA fragmentation in white blood ceils after diisocyanate exposure of workers [ J ]. Arch Toxico1,2003,77 ( 8 ) : 470-476.
  • 7Bolognesi C, Baur X, Marczynski B, et al. Carcinogenic risk of toluene diisocyanate and 4, 4'-methylenediphenyl diisocyanate: epidemiological and experimental evidence [ J]. Crit Rev Toxicol,2001,31 (6) :737-772.
  • 8Bilban M. Mutagenic testing of workers exposed to toluene- diisocyanates during plastics production process [ J]. Am J Ind Med, 2004,45 ( 5 ) :468-474.
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  • 10National Toxicology Program. Toxicology and carcinogenesis studies of commercial grade 2,4 ( 80% ) and 2,6 ( 20% ) toluene diisocyanate (cas. 26741-62-5 ) in F344/N rats and B6C6F1 mice (gavage studies)[ R]. Natl Toxicol Program Tech Rep Ser, 1986,3-56.

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毒理学杂志
2006年 第1期

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