摘要
目的观察不同剂量纳洛酮治疗急性安眠药、酒精混合中毒的临床疗效。方法72例安眠药、酒精混合中毒患者随机分为纳络酮大剂量治疗组和常规剂量对照组,分别给予纳洛酮0.8～1.6mg/d和4～12mg/d治疗。结果大剂量纳络酮治疗组催醒时间、症状持续时间比常规剂量对照组短(P<0.05),催醒后头痛头晕、胃肠不适等症状比例比常规剂量对照组少(P<0.05),且未见明显药物不良反应。结论大剂量纳络酮治疗安眠药、酒精混合中毒的疗效优于常规剂量。
Objective To investigate the effect of different dosage of Naloxone in treatment of acute intoxication of hypnotic and alcohol. Methods 72 patients suffering from intoxication of hypnotic and alcohol were randomly divided into two groups： one group received 0.8-1.6mg/d Naloxone and the other group received 4-12mg/d. Results The time of anabiosis and the duration of symptom after awake in high-dose group were significantly shorter than that of low-dose group （P〈0.05）. The ratio of headache and faint, uncomfortable of gastrointestinal and so on were significantly fewer than that of low-dose group （P〈0.05）, and it had few side effects. Conclusion The therapeutic effects of high-dose of Naloxone for acute intoxication of hypnotic and alcohol is significantly superior to low-dose.
出处
《中国现代医药杂志》
2006年第2期28-30,共3页
Modern Medicine Journal of China
