摘要
目的探讨梗阻性黄疸(梗黄)病人围手术期血清白细胞介素-2(IL-2)活性和可溶性白细胞介素-2受体(SIL-2R)表达状况及 IL-2/SIL-2R 系统平衡紊乱的临床意义。方法 39例梗黄病人(良性21例,恶性18例),分别采用放免计数器和双抗体夹心 ELISA 法测定血清 IL-2和 SIL-2R 水平。结果(1)良恶性两组术前血清 IL-2较对照组明显降低,SIL-2R 明显高于对照组,术后逐渐恢复,但良恶性两组变化幅度差异明显;(2)血清总胆红素与血清 IL-2及 SIL-2R 水平之间密切相关;(3)胆道外引流术式较内引流术式相对不利于梗黄病人术后血清 IL-2和 SIL-2R 水平的恢复。结论梗黄病人体内存在血清 IL-2/SIL-2R 系统平衡紊乱,监测血清 IL-2和 SIL-2R 有助于估价病情、判断预后及鉴别梗阻的性质,胆道外引流相对不利于血清 IL-2和 SIL-2R 的恢复。
Objective To investigate the changes in serum interleukin-2 （IL-2） and soluble interleukin-2 receptor （SIL-2R） levels and explore the clinical significance of IL-2/SIL-2R imbalance in patients with obstructive jaundice （OC）. Methods The 39 patients with OC were divided into the be nign group and malignant group. Serum IL-2 and SIL-2R levels were dynamically determined in both groups by radioimmunoassay and ELISA. Results Preoperative serum level of IL-2 in the 2 groups was significantly lower but that of SIL-2R higher than those in the normal control group. The postoperative serum levels of IL-2 and SIL2R gradually resumed in the 2 groups of patients. There was significant difference in the levels between the benign group and malignant group. Rank correlation analysis showed a relationship between the serum level of bilirubin and serum levels of IL-2 and SIL-2R. On day 7 and 12 following operation, serum IL-2 and SIL-2R levels in the benign patients treated by external biliary drainage did not resumed as compared with those by internal biliary drainage. Conclusions There is imbalance of serum IL-2/SIL-2R in patients with OC. Determination of serum IL-2 and SIL-2R levels might be a valuable method for estimating the patients＇ conditions, assessing the patients＇ prognosis and identifying the nature of external biliary drainage is relatively slow. OC. The recovery of serum IL-2 and SIL-2R levels by
出处
《中华肝胆外科杂志》
CAS
CSCD
2006年第1期11-13,共3页
Chinese Journal of Hepatobiliary Surgery
