摘要
目的:研究我国汉族人S-美芬妥英(S-Mep)4′-羟化代谢的遗传多态性。方法:148名互无血缘关系的汉族健康志愿者和5个家族21名成员,口服美芬妥英100mg后,用HPLC法测定0-12h尿中S-Mep 4′-羟化代谢的代谢比值(lg MR)和羟化指数(lg HI)。结果:lg MR和lg HI均呈两态性分布,分型点(antimode)分别为-1.00和1.50,羟化代谢缺陷的频发率为13.5％(20/148)。系谱分析表明S-Mep 4′-羟化代谢缺陷为常染色体隐性遗传。结论:S-Mep 4′-羟化代谢缺陷频发率东方人高于高加索人,遗传方式均为常染色体隐性遗传。
AIM: To study genetic polymorphism of S-mephenytoin (S-Mep) 4'-hydroxylation in the Chinese population of Han nationality. METHODS: The Ig metabolic ratio (MR) and Ig hydroxylation index (HI) in the urine (0 - 12 h) after oral administration with 100 mg of racemic Mep tablet were determined by HPLC method in 148 consangeously unrelated native Chinese subjects and 21 individuals of 5 families. RESULTS: The Ig MR and Ig HI showed a bimodal distribution with an antimode of - 1.00 and 1.50, respectively. The occurrence of poor metabolizers (PM) was 13.5 % in the population. The pedigree analysis in 5 families indicated that deficient S-Mep hydroxylation was an autoso-mal recessive trait. CONCLUSIONS: The occurrence of PM for S-Mep 4'-hydroxylation in Chinese was higher than that of the Caucasians, and both genetic modes were of autosomal recessive trait.
出处
《中国药理学报》
CSCD
1996年第2期119-121,共3页
Acta Pharmacologica Sinica
关键词
美芬妥英
表型
药物遗传学
汉族
药物代谢
解毒
S-mephenytoin
4'-hydroxyme- phenytoin
hydroxylation
phenotype
pedigree
pharmacogenetics
population
drug metabolic detoxication
