摘要
目的:探讨血清中细胞因子与慢性前列腺炎(Chronic prostatitis,CP)的关系。方法:用ELISA法检测36例慢性细菌性前列腺炎(Chronic bacterial prostatitis,CBP)和68例慢性非细菌性前列腺炎(Chronic abacterial prostatitis,CAP)患者血清中的细胞因子(IL-2、IL-4、IL-6、IL-8、TNF-α),同时,以20例健康男性作为正常对照,并对所取得的数据进行统计学处理。结果:(1)IL-2、IL-4在CBP、CAP患者血清中均有不同程度的升高,与正常对照组比较差异显著(P<0.05),CBP组与CAP组间比较无显著性差异(P>0.05)。(2)IL-6、IL-8、TNF-α在CBP、CAP与正常对照组间均有非常显著性差异(P<0.01),在CBP组与CAP组间差异显著(P<0.05或P<0.01)。结论:血清中IL-2、IL-4、IL-6、IL-8、TNF-α水平可能在CP的发生发展过程中起重要作用,对CP协助性诊断有较大应用价值,其中IL-6、IL-8、TNF-α对CP的诊断、分型有一定临床意义。
Objective： To investigate the relationship between levels of eytokines in serum and chronic prostatitis（CP）. Methods： The levels of interleukin-2（ IL-2）, interleuldn-4（IL-4）, interleuldn- 6（IL-6）, interleuldn-8（ IL- 8）, tumor necrosis factor-α（TNF-α） were detected in 36 eases of CBP,68 eases of CAP by ELISA, and 20 healthy men as control, and the results were statistically calculated. Results： ①The serum levels of IL-2, IL-4 in patients with CBP and CAP increased notably than those of control, and the difference was obvious between the patients with CBP or CAP and control （P〈0.05 ）, there was no significant difference between CBP and CAP（P〉0.05）. ②Tbe levels of IL-6, IL-8,TNF-α were significantly different between CBP or CAP and control （ P 〈 0.01 ）, the difference was obvious between CBP and CAP（ P 〈 0.05 or P 〈 0.01 ）.Conclusions： The levels of IL-2, IL-4, IL-6, IL-8, TNF-α in serum may play an important role in process of the occurrence and development of CP, and are of applied values to help diagnosis of CP, and IL-6, IL-8, TNF-α have certain clinical meaning to diagnosis and typing.
出处
《医学理论与实践》
2006年第3期266-267,共2页
The Journal of Medical Theory and Practice
