摘要
目的:制备GM-1的乳酸/羟基乙酸共聚物(PLGA)微球,考察其一般性质和体外释药特性。方法:应用W/O/W型乳化溶剂干燥法制备GM-1的PLGA微球,测定微球粒径、载药量、包封率和体外释药曲线。结果:微球形态规则,粒径约为(18±8)μm,载药量约为4.9%,包封率约为61%,微球体外释药规律符合Higuichi方程Q=0.153t1/2+0.03705(r=0.9950)。结论:GM-1微球体外释药特性及其制备工艺良好,体外具有明显缓释作用。
Objective： To prepare GM- 1 PLGA micmspheres and to investigate their general properties and in vitro drug release characteristics. Methods： The GM- 1 PLGA microspheres were prepared by W/O/W emulsion- solvent evaporation technique. To measure the particle size, drag loading amount, encapsulation efficiency and in vitro release curve. Results： The shape of optimized microshperes was good, particle size was about （18±8）μm, drag loading amount was about 4.9% and encapsulation efficiency was about 61%. The in vitro release profile was figured by Higuichi equation： Q =0. 153t61/2 ＋0. 037 05（ r=0. 995 0）. Conclusion： The GM - 1 PLGA microspheres have excellent pharmaceutical properties and sustained release characteristics.
出处
《中国药业》
CAS
2006年第3期48-49,共2页
China Pharmaceuticals
