期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

高血压药物的药物基因组研究进展 被引量：2

Pharmacogenomics of Drugs Acting on Hypertension
暂未订购
导出
摘要 遗传能影响药物在体内不同水平上的药物动力学和药效学。现从多因子疾病的多态性,多态性与抗高血压药物效果以及4组候选基因(肾素-血管紧张素系统基因、α-引导基因、盐敏感高血压的相关基因和Gsα基因)的研究进展,通过确定其药物反应的遗传标记,对其遗传背景进行个性化评估,从而选择更适合个体的抗高血压治疗,以达到更好地控制高血压的目的。 Genetics can influence the pharmacokinetics and pharmacodynamics of drugs at different levels. This review focus on the progress of polymorphisms in multifactorial diseases, polymorphisms and the efficacy of antihypertensive treatment and 4 candidate gene studies （ renin-angiotensin system genes, α-addatcin gene, genes associated with salt-sensitive hypertension and Gsα gene）. Through the identification of genetic markers of drug response arid the evaluation of their genetic background,which will help us to achieve a better way of antihypertensive therapy to individual patients and getting a better control of blood pressure in the population.
作者 陈宇 祝善俊
机构地区 第三军医大学大坪医院心内科 第三军医大学新桥医院心内科
出处 《心血管病学进展》 CAS 2006年第2期230-232,共3页 Advances in Cardiovascular Diseases
关键词 遗传药理学 高血压 多态性 pharmacogenetics hypertension polymorphisms
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献20

  • 1Sharma P,Fatibene J,Ferraro F,et al.A genome-wide search for susceptibility loci to human essential hypertension[J].Hypertension,2000,35:1291-1296.
  • 2Venter JC,Adams MD,Myers EW,et al.The sequence of human genome[J].Science,2001,291:1304-1351.
  • 3Iaeoviello L,di Castelnuovo A,de Knijff P,et al.Polimorphisms in the coagulation factor Ⅶ gene and the risk of myocardial infarction[J].N Engl J Med,1998,338:79-85.
  • 4Broly F,Marez D,Sabbagh N,et al.An efficient strategy for detection of know and new mutations of the CYP2D6 gene using single strand conformation polymorphisms analysis[J].Pharmacogenetics,1995,5:373-384.
  • 5Franke S,Klawitz I,Sehnakemberg E,et al.Isolation and mapping of a cosmid clone containing the human NAT2 gene[J].Biochem Biophys Res Commun,1994,199:52-55.
  • 6Mayer G.ACE genotype and ACE inhibitor response in kidney disease:a perspective[J].Am J Kidney Dis,2002,40:227-235.
  • 7Baudin B.Angiotensin Ⅱ receptor polymorphisms in hypertension.Pharmacogenomic considerations[J].Pharmacogenomics,2002,3:65-73.
  • 8Dudley C,Keavney B,Casadei B,et al.Prediction of patient response to antihypertensive drugs using genetic polymorphisms:investigation of renin-angiotensin system genes[J].J Hypertens,1996,14:259-262.
  • 9Stavroulakis GA,Makris TK,Krespi PG,et al.Predicting response to chronic antihypertensive treatment with fosinoprit:the role of angiotensin-converting enzyme gene polymorphism[J].Cardiovasc Drugs Ther,2000,14:427-432.
  • 10Kurland L,Melhus H,Karlsson I,et al.Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin Ⅱ receptor type 1 antagonist treatment in hypertensive patients[J].J Hypertens,2001,19:1783-1787.

同被引文献45

  • 1[1]Schelleman H,Klungel OH,van Duijn CM,et al.Drug-gene interaction between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and antihypertensive therapy[J].The Annals of Pharmacotherapy,2006,40(2):212-218.
  • 2[2]Trotta R,Donati MB,Iacoviello L.Trends in pharmacogenomics of drugs acting on hypertension[J].Pharmacological Research,2004,49(4):351-356.
  • 3[3]Turner ST,Schwartz GL.Gene markers and antihypertensive therapy[J].Current HypertensionRreports,2005,7(1):21-30.
  • 4[4]Minushkina LO,Zateishchikov DA,Sidorenko BA.Individual sensitivity to antihypertensive drugs:genetic aspects[J].Kardiologiia,2005,45(7):58-65.
  • 5[6]Arnett DK,Claas SA,Glasser SP.Pharmacogenetics of antihypertensive treatment[J].Vascular Pharmacology,2006,44(2):107-118.
  • 6[8]Manunta P,Bianchi G.Pharmacogenomics and pharmacogenetics of hypertension:update and perspectives--the adducin paradigm[J].Journal of the American Society of Nephrology,2006,17(4):30-35.
  • 7[9]Garcia EA,Newhouse S,Caulfield MJ,et al.Genes and Hypertension.[J] Current Pharmaceutical Design,2003,9(21):1679-1689.
  • 8[10]Koopmans RP,Insel PA,Michel MC.Pharmacogenetics of hypertension treatment:a structured review[J].Pharmacogenetics,2003,13(12):705-713.
  • 9[11]Sciarrone MT,Stella P,Barlassina C,et al.ACE and α-adducin polymorphism as markers of individual response to diuretic therapy[J].Hypertension,2003,41(3):398-403.
  • 10[13]Schelleman H,Stricker BHC,Boer AD,et al.Drug-Gene Interactions between Genetic Polymorphisms and Antihypertensive Therapy[J].Drugs,2004,64 (16):1801-1816.

引证文献2

二级引证文献11

心血管病学进展
2006年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部