摘要
目的:定量研究存在于通道中的记忆并提供有关统计方法以应用于生物医学研究。方法:利用随机过程分别建立短期和长期两类记忆的模型,坚持两状态而不是多状态,只是转移机制不同。结果:恒定转移强度的二状态马氏过程较好地拟合短期记忆的情形,处于一类随机环境中的二状态马氏过程较好地拟合长期记忆的情形;提出了参数估计的方法并以PC12细胞通道作为示例。结论:离子通道中的记忆可以用仅含两个状态的随机过程定量地建立模型。
AIM: To study quantitatively the memory existing in ion channels. METHODS: Stochastic processes were used to model 2 categories of memory (short-term and long-term) by persisting in the standpoint of two-state, instead of multiple states, but with different transition mechanism. RESULTS: A two-state Markov process with constant transition intensities well fitted the short-term memory and a two-state Markov process within a kind of random environment well fitted the long-term memory. Statistical procedures for parameter estimation were proposed and demonstrated with 2 real examples on the channels of PC12 cells. CONCLUSION: The memory in ion channels can be quantitatively modelled as stochastic process with 2 states.
出处
《中国药理学报》
CSCD
1996年第1期13-18,共6页
Acta Pharmacologica Sinica
基金
Project supported by the National Natural Science Foundation of China,№ 39170222.
关键词
离子通道
记忆
统计学模型
ion channels
statistical models
memory
