摘要
目的:观察纯化花粉(黄蒿、葎草、藜草花粉)变应原特异性免疫治疗(SIT)的疗效.方法:采取凝胶过滤方法分别提纯上述花粉变应原.采取随机、对照方法将102例确诊为季节性黄蒿、葎草、藜草花粉过敏性哮喘患者分为观察组(A组)及对照组(B组),应用纯化花粉变应原(PPA)及粗花粉变应原(CPA)分别对两组患者进行季节前SIT,疗程3mo.临床疗效判断标准为显效、好转及无效.临床不良反应观察包括局部或全身皮疹、哮喘加重等.实验观察指标为两组SIT前后的皮肤试验(ID)风团直径、特异性IgE(sIgE)、A值均值.结果进行组内和组间比较.结果:A组SIT总有效率90%(47/52),B组78%(39/50),前者明显高于后者(P<0.05);A组仅3例轻度副反应,B组有13例(26%)出现副反应;A组及B组SIT后ID风团直径、sIgE,A值均值都较SIT前明显下降(P<0.01);A组SIT后上述指标下降程度较B组更明显(P<0.05).结论:PPA及CPA的SIT疗效均较满意,但用PPA进行SIT的安全性和疗效更好.
AIM： To study the effect of specific immunotherapy （SIT） with purified pollen allergens （caraway, humulus and chenopodium） on asthmatic patients. METHODS： The pollen allergens were purified by gelatin filtration. One hundred and two patients with seasonal asthma allergic to caraway, humulus or chenopodium pollen were divided randomly into 2 groups ： observation group （ group A） and control group （ group B） and the 2 groups were given purified pollen allergens （PPA） and crude pollen allergens （CPA） respectively before the allergic season. The course was 3 months. The laboratory observation included the wheals＇ diameter of ID, specific IgE （sIgE） and mean A value before and after SIT. RESULTS： The general effective rate of SIT with purified allergens in group A was 90% （47/52） and that with crude allergens in group B was 78% （39/50）. The former was significantly higher than the latter （P 〈 0. 05 ）. Only 3 patients in group A had slight side-effects after SIT and 13 patients （26%） in group B had side-effects. A significant decrease in the diameter of skin wheal and slgE （ P 〈 0. 01 ） was observed after SIT in both groups and the decrease was more sig nificant in group A than in group B （ P 〈 0.05 ）. CONCLUSION： The effective rates of SIT with both PPA and CPA are satisfactory. But SIT with PPA is more effective and safer than that with CPA.
出处
《第四军医大学学报》
CAS
北大核心
2006年第5期466-468,共3页
Journal of the Fourth Military Medical University
关键词
哮喘
纯化花粉变应原
免疫疗法
asthma
purified pollen allergens
immunotherapy
