摘要
目的通过研究脾酪氨酸激酶(Syk)在胃癌、癌前病变、慢性胃炎及正常胃黏膜中的表达情况,探讨Syk表达与胃癌生成与转移的关系及意义。方法采取免疫组织化学法对正常胃黏膜及不同病变胃黏膜组织标本中Syk蛋白进行检测。结果Syk在胃癌组织中表达明显减弱,其阳性率为35.00%,显著低于正常胃黏膜、慢性浅表性胃炎、慢性萎缩性胃炎伴肠化生和不典型增生胃黏膜组织(100%,95%,86.36%,76.19%;P<0.05);Syk蛋白表达缺失与胃癌分期、淋巴结转移有关(P<0.05)。结论Syk蛋白在胃癌中表达缺失,Syk表达缺失与胃癌的生长和转移有关。
Objective..To investigate the expressions of spleen tyorosine kinase（Syk） protein in human gastric carcinoma, precarcinoma changes, chronic inflammation, normal gastric mucosa and to identify＇the significance of expressions of Syk, Methods ：Immunohistochemistry method was applied to detect the expressions of Syk in normal gastric mucosa, various gastric changes tissue specimens. Results：The rate of positive Syk expression in gastric carcinoma reduced significantly（35 % ） and was lower significantly than that in normal gastric mucosa ,chronic superficial gastritis ,chronic atrophic gastritis with intestinal metaplasia and atyptical hyperplasia tissues （100%, 95 %, 86.36% ,76. 19 % % ;P〈0.05 respectively） ;The depletion of Syk expression was related to tumor stages and lymphnode metastasis （P〈0.05）. Conclusion： There was the depletion of Syk expression in gastric carcinoma. The expression of Syk may play an important role in suppressing growth and metastasis of gastric cancer.
出处
《中国误诊学杂志》
CAS
2006年第3期411-412,共2页
Chinese Journal of Misdiagnostics
