摘要
目的观察医院内制剂复方三黄散颗粒(FSHS)治疗艾滋病的有效性、安全性及其作用机理。方法以共用注射器静脉注射海洛因4年以上、CD4+细胞<400/μl、艾滋病病毒(HIV)载量>400拷贝/ml的80例艾滋病患者为对象。用抽签法随机分为治疗组(41例)及对照组(39例),治疗组用FSHS,对照组用安慰剂,两组皆给予对症治疗。结果治疗组41例中13例(31.71%)CD4+T淋巴细胞上升>30%,2例(4.88%)上升>25%;11例(26.82%)HIV载量下降>0.5log。治疗组总有效率为63.41%,对照组总有效率为33.33%,两组有效率的差异有显著的统计学意义(P<0.05)。药效学研究显示,FSHS对HIV逆转录酶和整合酶有一定抑制作用,并能使免疫抑制小鼠外周血CD4+T淋巴细胞升高。84%患者临床症状改善,36.59%的病例CD4+T淋巴细胞升高达标,26.82%的病例HIV载量下降>0.5log。急性毒性试验显示无毒,6个月的长期毒性试验证明无明显毒性,血细胞分析、肝肾功能未见与本药相关的异常。结论FSHS疗效较好,副作用小,药源丰富,价廉,是发展中国家艾滋病患者经济能力能承担的药物。
Objective To explore the effectiveness safety and mechanism of FSHS.Methods 80 cases were selected from 1 000 injection drug users by interrogation,physical examination and physlcochemical examination according to the diagnostic criteria of CDC in the United States in 1993 on HIV/AIDS. The 80 cases were divided into therapeutic group and control group at random. Both groups received symptomatic treatment. The therapeutic group took FSHS, while the control group took placebo. Results After treatment for 6 months,the effective rate was 63.41% in the therapeutic group and 33.33% in the control group.Conclusion The FSHS showed a good effect （the symptoms improved,CD4^＋ T cells increased and HIV load reduced）, the side-effect was very mild, the pharmaceutical source was very rich and the price is cheaper than some western medicines. The acute toxicity test and long term toxicity test showed that FSHS had no obvious toxicity.
出处
《中国艾滋病性病》
CAS
2006年第1期21-23,共3页
Chinese Journal of Aids & STD
