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具有抗肿瘤作用的维甲酸类化合物的研究进展 被引量：7

Progress in the Research of the Retinoids with Antitumor Activity
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摘要 综述具有抗肿瘤活性的维甲酸类化合物的研究现状,并展望其今后的研究动向。维甲酸类化合物通过激活其核受体蛋白来调控核基因的表达,产生抗肿瘤作用,其中一些有望成为临床抗肿瘤药物。 The recent researches on retinoids with anticancer activity were reviewed. And future trends in the research of retinoids as anticancer medicines were also presented. Retinoids regulate the gene expression by activating two kinds of receptors： retinoic acid receptor and retinoid x receptor, and have protective effects against the development of certain types of cancer. Some retinoids may become the promising candidates of clinical anticancer medicines.
作者 郝北辰 张奕华
机构地区 中国药科大学新药研究中心
出处 《药学进展》 CAS 2006年第2期65-69,共5页 Progress in Pharmaceutical Sciences
关键词 维甲酸类化合物 维甲酸受体 抗肿瘤活性 Retinoids Retinoic acid receptor and retinoid x receptor Anticancer activity
分类号 R979.1 [医药卫生—药品] R914.2 [医药卫生—药物化学]
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参考文献20

  • 1Niles R M.Recent advances in the use of vitamin A (retinoids) in the prevention and treatment of cancer[J].Nutrition,2000,16(11/12):1084-1089.
  • 2Merino R,Hurle J M.The molecular basis of retinoid action in tumors[J].Trends Mol Med,2003,9(12):509-511.
  • 3Lei M,de Thé H.Retinoids and retinoic acid receptor in cancer[J].EJC Supplements,2003,1(2):13-18.
  • 4Pfahl M,Piedrafita F J.Retinoid targets for apoptosis induction[J].Oncogene,2003,22(56):9058-9062.
  • 5Cincinelli R,Dallavalle S,Nannei R,et al.Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with anti-proliferative and proapoptotic activity[J].J Med Chem,2005,48(15):4931-4946.
  • 6Farmer L J,Zhi L,Jeong S,et al.Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid[J].Bioorg Med Chem Lett,2003,13(2):261-264.
  • 7Koichi Shudo,Hiroyuki Kagechika,Emiko Kawachi,et al.Retinobenzoic acids.1.Structure-activity relationships of aromatic amides with retinoidal activity[J].J Med Chem,1988,31(11):2182-2192.
  • 8Beard R L,Duong T T,Teng M,et al.Synthesis and biological activity of retinoic acid receptor-alpha specific amides[J].Bioorg Med Chem Lett,2002,12(21):3145-3148.
  • 9Masaaki Kurihara,Abu Shara Shamsur Rouf,Hisao Kansui,et al.Design and synthesis of cyclic urea compounds:a pharmacological study for retinoidal activity[J].Bioorg Med Chem Lett,2004,14(16):4131-4134.
  • 10李勤喜,王流芳,刘映琦,王印月.维甲酸镍配合物(Ni(RA)_2·3H_2O)抗白血病HL-60细胞的研究[J].厦门大学学报（自然科学版）,2003,42(6):795-799. 被引量：1

二级参考文献17

  • 1王皓.几种常用恶性肿瘤体外化疗药物敏感性预测法的临床应用与评价[J].国外医学（肿瘤学分册）,1994,21(1):23-27. 被引量：7
  • 2夏丽娟,景永奎,韩锐.一种快速的癌分化诱导剂筛选方法[J].中华血液学杂志,1994,15(2):99-101. 被引量：17
  • 3张一军.应用维甲酸治疗肿瘤的研究现状[J].国外医学（输血及血液学分册）,1995,18(5):294-297. 被引量：5
  • 4王振义 孙关林 等.全反式维甲酸治疗急性早幼粒细胞白血病90例的临床研究[J].中华血液学杂志,1990,11(9):480-480.
  • 5李学汤.肿瘤细胞化学技术进展及应用[J].国外医学：肿瘤学分册,1984,11(2):69-74.
  • 6Fenaux P. Castaigne S. Domret H. et al. All-trans retinoic acid followed by intensive ehemotherapy gives a high complete remission rate and may prolong remissions in newly diagnosed acute promyelocytic leukemi-a: a pilot study on 26 cases[J]. Blood, 1992, 80(9):2 176--2 181.
  • 7Haley T J. Pharmacology and toxicology of the rare earthelements[J].J Pharm Sci, 1965, 54(5): 663--670
  • 8Liu Y M, Wang L F. Antitumor activity of transition metal( Ⅱ ) complexes with all-trans retinoic acid[J].Transition Met Chem, 1999, 24:1--4.
  • 9Collins S J. et al. Induction of morphological and functional differentiation of human promyelocytic leukemia cells HL-60 by compounds which induce differentiation of murine leukemia cells[J]. Int J Cancer, 1980, 25:213.
  • 10Mosmann T. Rapid Colorimetric assay for cellular growth and Survival application to proliferation and cytotoxicity assay[J]. J Immunal Methods, 1983, 65:55.

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药学进展
2006年 第2期

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