摘要
AIM： TO assess the effect of iron reduction after phlebotomy in rats with ＂normal＂ hepatic iron concentration （HIC） on the progression of hepatic fibrosis, as a result of bile duct ligation （BDL）. METHODS： Rats underwent phlebotomy before or after sham operation or BDL. Animals undergone only BDL or sham operation served as controls. Two weeks after surgery, indices of hepatic damage and fibrosis were evaluated. RESULTS： Phlebotomy lowered HIC. Phlebotomy after BDL was associated with body weight increase, lower hepatic weight, less portal hypertension, less periportal necrosis, less portal inflammation, lower hepatic activity index score and higher albumin levels. On the other hand, phlebotomy before BDL was associated with body weight decrease and hepatic activity index score increase. Phlebotomy after sham operation was not associated with any hepatic or systemic adverse effects. CONCLUSION： Reduction of HIC after induction of liver damage may have beneficial effects in BDL rats. However, iron deficiency could induce impairment of liver function and may make the liver more susceptible to insults like BDL.
瞄准：在肝的纤维变性的前进上与“正常”的肝的铁集中(HIC ) 在老鼠在静脉切开放血术以后估计铁减小的效果，由于胆汁管结扎(BDL ) 。方法：老鼠在假冒的操作或 BDL 前后经历了静脉切开放血术。经历的动物仅仅 BDL 或假冒的操作用作控制。在外科以后的二个星期，肝的损坏和纤维变性的索引被评估。结果：静脉切开放血术降低了 HIC。在 BDL 以后的静脉切开放血术与体重增加，更低的肝的重量，更少的门静脉高血压，更少的仙子门坏死，更少的门发炎，更低的肝的活动索引分数和更高的白朊层次被联系。在另一方面，在 BDL 前的静脉切开放血术与体重减少和肝的活动索引 20 增加被联系。在假冒的操作以后的静脉切开放血术没与任何肝或全身的不利效果被联系。结论：在肝损坏的正式就职以后的 HIC 的减小可以在 BDL 老鼠有有益的效果。然而，铁缺乏能导致肝功能的缺陷并且可以使肝更易受影响到象 BDL 一样的侮辱。
