摘要
Cadherin is an adhesion molecule and a superfamily of calcium-mediated membrane glycoproteins. E-cadherin is the prototype of the class E-cadherin that links to catenins to form the cytoskeleton. Recent evidence has shown that E-cadherin not only acts as an adhesive, but also plays important roles in growth development and carcinogenesis. It has been recently viewed as an invasion as well as a growth suppressor gene. This review summarizes the recent discoveries on E-cadherin and its role in gastric cancer. In particular, our work on E-cadherin in gastric cancer, including its relation with Helicobacter pylori and clinical applications, are described in detail.
Cadherin 是一个粘附分子和调停钙的膜 glycoproteins 的一个总科。E-cadherin 是连接到 catenins 形成细胞骨架的班 E-cadherin 的原型。最近的证据显示出那 E-cadherin 不仅充当粘合剂，而且在生长开发和致癌作用起重要作用。它最近被看作了侵略以及生长压制或基因。这评论在胃的癌症在 E-cadherin 和它的角色上总结最近的发现。特别地，包括它有 Helicobacter pylori 和临床的应用的关系，我们在胃的癌症的 E-cadherin 上的工作详细被描述。
