摘要
目的探讨急性结膜炎痊愈后泪膜的变化规律。方法选择2002年7月至2003年8月,在中山眼科中心就诊,经常规治疗在自然病程内痊愈的急性结膜炎连续患者56例(73只眼),并排除其他影响泪膜的因素,分别于痊愈后3、7、14、21、30d行泪膜破裂时间(BUT)、角膜荧光素染色(FL)、基础泪液分泌试验(SchirmerⅠtest,ST)及泪河高度测量,并与未发病眼对照比较。结果未发病眼BUT为14.72s,痊愈后第3、7、14、21天,BUT分别为5.23、5.11、7.84、10.26s(P=0.012、0.018、0.032、0.028),第30天,BUT为12.74s(P=0.122)。未发病眼FL评分为2.26,痊愈后第3、30天,FL评分分别为3.02、3.53(P=0.063、0.074),第7、14、21天,FL评分分别为6.23、7.92、6.37(P=0.017、0.008、0.024)。未发病眼ST为16.30mm,痊愈后第3、7、21天,ST分别为9.39、11.48、21.24mm(P=0.025、0.040、0.012),第14、30天,ST分别为13.85、17.40mm(P=0.082、0.104)。未发病眼泪河高度为0.62mm,痊愈后第3、7、14天,泪河高度分别为0.39、0.32、0.44mm(P=0.008、0.015、0.037),第21、30天,泪河高度分别为0.53、0.58mm(P=0.120、0.182)。结论急性结膜炎痊愈后可出现泪膜不稳定和暂时性干眼症;治疗急性结膜炎时充分考虑药物对泪膜的副作用,减少不必要用药可预防干眼症的发生。
Objective To investigate tear film changes after recovery from acute conjunctivitis. Methods This study involved 73 eyes of 56 consecutive patients who had recovered from acute conjunctivitis after routine treatment in Zhongshan Ophthalmic Center between July 2002 and August 2003. Excluded other factors which could affect the stability of the tear film, tear film break up time （ BUT）, Schirmer Ⅰ test （ ST）, fluorescein staining （FL） and the height of tear meniscus were measured on both recovered and healthy eyes of the patients at 3, 7, 14, 21 and 30 days after recovery. Results BUT was 14.72 s in healthy eyes, 5.23, 5.11, 7. 84, 10. 26 and 12. 74 s in recovered eyes at 3, 7, 14, 21 and 30 days （P=0.012, 0.018, 0.032, 0.028 and 0. 122） , respectively. FL scored at 2.26 in healthy eyes, 3.02, 6. 23, 7.92, 6. 37 and 3.53 at 3, 7, 14, 21 and 30 days in recovered eyes （P = 0. 063, 0. 017, 0.008, 0.024 and 0.074）, respectively. ST scored at 16.30 mm in healthy eyes, 9.39, 11.48, 13.85, 21.24 and 17.40 ram, at 3, 7, 14, 21 and 30 days in recovered eyes （P =0. 025, 0. 040, 0. 082, 0. 012 and 0. 104）, respectively. The height of tear meniscus was 0. 62 mm in healthy eyes ; it scored at 0. 39, 0.32,0.44, 0.53 and 0.58 mm at 3, 7, 14, 21 and 30 days in recovered eyes （P=0.008, 0.015, 0. 037, 0. 120 and 0. 182） , respectively. Conclusions Instability of tear film and transient dry eye can occur after recovery from acute conjunctivitis. However, dry eye can be avoided during the treatment of acute conjunctivitis by consideration of drug side effects to the tear film and minimizing the unnecessary use of drugs.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2006年第2期159-161,共3页
Chinese Journal of Ophthalmology
关键词
结膜炎
泪器
干眼病
Conjunctivitis
Lacrimal apparatus
Xerophthalmia
