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他汀类药物防治心肌肥厚的分子机制的研究进展 被引量：3

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摘要 心肌肥厚是引起心血管疾病发生率和死亡率显著升高的独立的危险因素。他汀类药物是目前临床应用最广泛、最有效的降脂药物,其通过调控细胞外的刺激信号、细胞内的信号转导和细胞核内的基因转录的活化等多个信号传导环节,影响小三磷酸鸟苷结合蛋白、丝裂素活化蛋白激酶、肾素-血管紧张素系统和过氧化物酶体增殖物激活受体途径的活性,增加一氧化氮水平并发挥抗氧化应激和抗炎作用,从而阻止心肌肥厚的发生、发展,降低心脏疾病的死亡率。他汀类药物的上述作用为心肌肥厚的防治提供了新的可能性。
作者 盛莉 叶平 刘永学
机构地区 中国人民解放军总医院老年心内科 军事医学科学院放射医学研究所
出处 《中国动脉硬化杂志》 CAS CSCD 2005年第5期646-648,共3页 Chinese Journal of Arteriosclerosis
关键词 内科学 心肌肥厚 他汀类药物 分子机制 综述
分类号 R5 [医药卫生—内科学]
  • 相关文献

参考文献26

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二级参考文献30

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共引文献28

同被引文献44

  • 1赵水平,王小清,李全忠,唐汉权.阿托伐他汀及血管紧张素Ⅱ对人体脂肪组织白细胞介素6及Ⅰ型纤溶酶原激活剂抑制物分泌的影响[J].中国动脉硬化杂志,2005,13(1):73-75. 被引量：3
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引证文献3

二级引证文献12

中国动脉硬化杂志
2005年 第5期

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