摘要
目的研究基质金属蛋白酶1基因多态性与冠心病的关系。方法运用聚合酶链反应检测62例冠心病患者(急性冠状动脉综合征35例,稳定型心绞痛患者27例)及31例正常对照者基质金属蛋白酶1基因型,并运用高频超声技术检测双侧颈动脉。结果急性冠状动脉综合征患者基质金属蛋白酶1基因2G/2G型、2G等位基因频率均明显高于稳定型心绞痛患者及正常对照者,颈动脉脂质型斑块基质金属蛋白酶1基因2G/2G型、2G等位基因频率均明显高于纤维型和钙化型斑块,基因型及等位基因频率分布差异均有统计学意义。结论急性冠状动脉综合征、稳定型心绞痛患者及正常对照者基质金属蛋白酶1基因分布存在不同。2G/2G型、2G等位基因与动脉粥样硬化斑块不稳定性可能有关。
Aim To investigate the association between polymorphism of matrix metaUoproteinase 1 （ MMP-1 ） and coronary heart disease. Methods This study enrolled 35 patients with acute coronary syndrome, 27 patients with stable angina （SA）, 31 normal volunteers. The carotid arteries were performed with echocardiography. With PCR, genotypes of MMP-1 were scored according to the patterns of DNA bands. Results The frequency of MMP-1 2G/2G type and allele T was significantly higher in ACS group than SA group and control group. The frequency of MMP-1 2G/2G type and allele T was significantly higher in fatty plaque than fibrous plaque and calcify plaque. Conclusion There was association between the acute coronary syndrome and the 2G/2G type of MMP-1.
出处
《中国动脉硬化杂志》
CAS
CSCD
2005年第5期589-592,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金资助(60271015)
