摘要
目的观察生大黄对脓毒症患者血浆D乳酸和前降钙素的影响。方法前瞻、随机抽取符合入选条件的脓毒症患者40例,分为治疗组(18例)和对照组(22例)。治疗组给予生大黄9g/d,对照组给予常规治疗,于治疗前和治疗后测定患者血浆D乳酸和前降钙素水平。结果治疗前治疗组患者的血浆D乳酸水平(mmol/L)0.18±0.05和前降钙素水平(μg/L)6.50±2.37,与对照组(0.19±0.06、6.98±2.89)比较,差异无显著性(P>0.05);治疗后治疗组血浆D乳酸水平0.09±0.03和前降钙素水平2.21±0.61较对照组(0.24±0.06、4.11±1.40)明显下降(P<0.05)。结论生大黄能改善脓毒症患者肠道黏膜通透性,减少肠道细菌移位,减轻脓毒症。
Objective To investigate the effects of raw rhubarb （RR） on levels of plasma D-lactate and procalcitonin in patients with sepsis. Methods Forty patients with sepsis enrolled were randomly divided into two groups, the RR group （n = 18, treated with RR 9 g/d） and the control group （n -22, treated with conventional treatment）. Plasma procalcitonin and D-lactate were determined before and after treatment. Results Before treatment, there was no significant difference in the levels of plasma procalcitonin and D-lactate between the two groups （procalcitonin ： 6.50 ± 2.37 μg/L vs 6.98 ± 2.89 μg/L; D-lactate： 0.18 ± 0.05 mmol/L vs 0.19 ± 0.06 mmol/L, P 〉0.05）. However, after treatment, two indexes in the RR group were significantly lower than those in the control group （procalcitonin： 4.11 ± 1.40 μg/L vs 2.21 ± 0.61 μg/L; D-lactate： 0.24 ± 0.06ng/L vs 0.09 ± 0.03ng/L, both P 〈 0.05）. Conclusion RR could ameliorate the intestinal permeability and reduce the shifting of intestinal bacteria, so as to ease the condition of disease in patients with sepsis.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2006年第2期128-130,共3页
Chinese Journal of Integrated Traditional and Western Medicine
