摘要
目的探讨冠心病(CHD)患者的胰岛素抵抗与肿瘤坏死因子(TNF-α)的关系。方法选择冠心病患者 48例,对照组28例,分别应用氧化酶法、放免法和酶联免疫法测定其空腹及餐后2小时血糖,血清胰岛素(INS)及 TNF-α值,计算胰岛素敏感性指数。结果冠心病组存在高胰岛素血症及胰岛素抵抗,并且血清ISI水平与TNF-α呈显负相关。结论胰岛素抵抗程度与TNF-α水平升高密切相关。二者相互影响、相互促进、共同参与冠心病的发生与发展过程。
Objective： To study the relationship between insulin resistance and TNF-α in coronary heart disease （CHD）. Methods： Blood-glucose, serum insulin level and TNF-α were measured in 48 CHD cases and 28 healthy controls by oxidase method, RIA and ELISA respectively. Insulin sensitivity index （ISI） was also calculated. Results： CHD patients showed insulin resistance and hyperinsulinemia, and the ISI was negatively correlated with TNF-α. Conclusion： The degree of insulin resistance correlates with high TNF-α level. Interaction between hyperinsulinemia and TNF-α may be involved in the development of CHD.
出处
《泰山医学院学报》
CAS
2005年第5期431-432,共2页
Journal of Taishan Medical College
关键词
冠心病
胰岛素抵抗
肿瘤坏死因子
coronary heart disease
Insulin resistance
tumor necrosis factor-α
