摘要
采用ＭＴＴ、ＨＰＬＣ等方法对膀胱癌耐药细胞耐药性逆转进行实验研究，以钙通道阻断剂异搏定为逆转剂。结果表明：异搏定能有效地逆转膀胱癌细胞的抗药性，主要通过抑制Ｐ－ＧＰ糖蛋白的药物外流“泵”作用，增加了细胞内长春新碱（ＶＣＲ）的蓄积。抗药逆转剂（异搏定）与化疗药物联合应用进行膀胱腔内灌注可能是治疗和预防膀胱肿瘤抗药及复发的有效手段。
Verapamil,a calcium channel antagonist,was used as the reversal reagent for drug resistance in bladder tumor.The result denoted that verapamil could reverse effectively the drug resistance of bladder tumor and would inhibit the drug efflux pump effect of P-GP glycoprotein, increasing vincristine accumulation in cells.It was suggested that verapamil combined with intravesical instillation of chemotherapeutic agents might be an effective means of preventing drug resistance and recurrence of bladder tumor.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1996年第4期207-209,共3页
Chinese Journal of Urology
