1Rougier P,van CutsemE,Bajetta E,et al.Randomizedtrial of irino-tecan vs fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer[].The Lancet.2000
2Advanced CRC.Meta-analysis Project.Modulation of fluorouracil byleucovorinin patients with advanced colorectal cancer:evidencein terms of response rate[].Journal of Clinical Oncology.1992
3Lockhart C,Berlin JD.The epidermal growth factor receptor as a target for colorectal cancer therapy[].Seminars in Oncology.2005
4De Gramont A,Figer A,Seymour M,et al.Leucovorin andfluoroura-cil with or without oxaliplatin as first-line treatment in advanced colorectal cancer[].Journal of Clinical Oncology.2000
5Greenlee RT,Hill-Harmon MB,Murray T,et al.Cancer statistics2001[].CA A Cancer Journal for Clinicians.2001
6Giacchetti S,Perpoint B,Zidani R,et al.Phase III multicenter ran-domizedtrial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer[].Journal of Clinical Oncology.2000
7De Gramont A,Bosset JF,Milan C,et al.Randomizedtrial comparing monthlylow-dose leucovorin and fluorouracil bolus with bi monthly high-dose leucovorin and fluorouracil bolus plus infusion for ad-vanced colorectal cancer:a French Intergroup Study[].Journal of Clinical Oncology.1997
8Scheithauer W,Rosen H,Kornek GV,et al.Randomized comparison of combination chemotherapy plus supportive care or supportive care alonein patients with metastatic colorectal cancer[].British Medical Journal.1993
9Saltz LB,CoxJV,Blanke C,et al.Irinotecan plusfluorouracil andleu-covorin for metastatic colorectal cancer[].The New England Journal of Medicine.2000
