摘要
采用递增负荷力竭性运动模型，观察了ＳＤ大鼠急性运动至力竭后心肌和骨骼肌线粒体内膜流动性和ＡＴＰ酶活性的变化。发现心肌和骨骼肌线粒体内膜荧光偏振值和微粘度均较安静时增高，示内膜流动性显著降低（均Ｐ＜０．０１）；心肌和骨骼肌线粒体内膜ＡＴＰ酶活性分别较安静时下降７４．３％和４５．７％（Ｐ＜０．０１和Ｐ＜０．０５）。研究提示，力竭性运动后大鼠心肌和骨骼肌线粒体呼吸链内膜分子动力学改变直接影响内膜磷酸化过程，可能是运动性疲劳的线粒体膜分子特征之一。
The inner mitochondrial membrane(IMM)fluidity and ATPase activity of the heart and skeletal muscle after exhaustive exercise in rats were invcstigated. The results showed that the fluorescence polarization and microviscosity values of IMM in rat heart and skeletal muscle were higher than the resting values (p<0.01), which meant the IMM fluidity decreased obviously.The ATPase activity of the IMM in rat heart and skeletal muscle decreased by 74.3% and 45.7%respectively(p<0.01),p<0.05),compared with the resting state, It suggested that the changes of IMM respiratory chain molecular dynamics influenced the phosphorylation of the inner membrane directly after the exhaustive exercise and it might tw one of the mitoch ondrial membrane molecular characteristics in exercise-induced fatigue.
出处
《中国运动医学杂志》
CSCD
北大核心
1996年第2期110-113,共4页
Chinese Journal of Sports Medicine
关键词
疲劳
运动
心肌
骨骼肌
线粒体内膜
ATP酶
exhaustive exercise
heart and skeletal muscle
mitochondrial membr ane
fluidity
ATPase.
