摘要
目的观察了玻璃酸钠滴眼液对兔眼刺激性影响。方法计数兔眨眼次数、短期多次给药眼刺激(1次/15min,连续滴眼2h)和长期给药眼刺激(5次/日,连续滴眼4周)作用。结果玻璃酸钠滴眼液对兔眨眼次数与辅料对照液比较无明显差异(P>0.05)。短期多次及长期给药刺激试验对兔眼均无明显影响,双眼角膜透明,无混浊,虹膜纹理清晰,结膜无充血,无水肿、无分泌物。结论玻璃酸钠滴眼液临床应用是安全的。
OBJECTIVE To test the irritant effect of hyaluronic acid sodium eye drops on rabbit eyes. METHODS To count rabbit nictation times,short-time multiple eye drops irritation （once per 15 minute for continuously 2 hours） and long-time eye drops irritation （5 times per day for continuously 4 weeks）. RESULTS There is no significant difference on rabbit nictation times between hyaluronic acid sodium eye drops and excipient （P〉0. 05）. Furthermore,short-time multiple and long- time regular irritation have no markedly influences on tested rabbit eyes, both corneas are transparent without turbidness, and iris clarity,no conjunctiva hyperemia,no edema and no discharge. CONCLUSION Sodium hyaluyonate eye drops is safety for clinic application.
出处
《齐鲁药事》
CAS
2006年第2期116-117,共2页
qilu pharmaceutical affairs
关键词
玻璃酸钠滴眼液
兔眼
刺激性试验
Hyaluronic acid sodium eye drops
rabbit eyes
irritant test
