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着床前胚胎遗传学诊断的进展 被引量:1

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摘要 着床前胚胎遗传学诊断(PGD)于90年代初确立,该技术使遗传病的诊断提前至胚胎着床前,不仅避免了流产术,也使早期基因治疗成为可能。PGD材料可来自极体、卵裂球或胚泡,PCR和FISH是PGD中使用的二种主要分析技术。PGD目前应用于性别、单基因病和染色体病的诊断。PGD有一定的误诊率,未来的目标是提高其准确件和有效性。
出处 《国外医学(妇产科学分册)》 1996年第1期5-7,共3页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
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  • 1Y. Verlinsky,A. Handyside,J. Grifo,S. Munné,J. Cohen,I. Liebers,G. Levinson,N. Arnheim,M. Hughes,J. Delhanty,J. Harper,C. Mathews,A. Kuliev,J. L. Simpson,M. Monk,C. Strom,I. Findlay,R. Gore-Langton,S. Lansendorf,P. Braude,A. Muggleton-Harris,W. Lissens,N. Ginsberg,L. Jackson,S. Giltin,J. Fisher,C. Readhead,L. Wilton,P. Sutter,J. Selva,P. Ray,A. Thornhill,E. Kontogianni,M. Johnson. Preimplantation diagnosis of genetic and chromosomal disorders[J] 1994,Journal of Assisted Reproduction and Genetics(5):236~243
  • 2Yury Verlinsky,Dimitry Dozortsev,Sergei Evsikov. Visualization and cytogenetic analysis of second polar body chromosomes following its fusion with a one-cell mouse embryo[J] 1994,Journal of Assisted Reproduction and Genetics(3):123~131
  • 3Santiago Munné,Heinz-Ulrich G. Weier,Jonathan Stein,Jamie Grifo,Jacques Cohen. A fast and efficient method for simultaneous X and Y in situ hybridization of human blastomeres[J] 1993,Journal of Assisted Reproduction and Genetics(1):82~90

同被引文献3

  • 1吕永杰.荧光原位杂交及其在肿瘤生物学中的应用[J].国外医学(遗传学分册),1994,17(1):3-8. 被引量:2
  • 2Darren K. Griffin,Leeanda J. Wilton,Alan H. Handvside,Robert M. L. Winston,Joy D. A. Delhanty. Dual fluorescent in situ hybridisation for simultaneous detection of X and Y chromosome-specific probes for the sexing of human preimplantation embryonic nuclei[J] 1992,Human Genetics(1):18~22
  • 3Matteo Adinolfi,Paul E. Polani. Prenatal diagnosis of genetic disorders in preimplantation embryos: invasive and non-invasive approaches[J] 1989,Human Genetics(1):16~19

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