摘要
肺的基底细胞样癌少见，易与肺的其它类型的癌瘤相混淆。作者对本科１９７８～１９９３年经手术切除的５２例肺癌（以前诊断为低分化癌、未分化癌、类癌或腺癌伴类癌分化）病例的组织切片进行了回顾性复习后，８例再分类为基底细胞样癌，２例为灶性基底细胞样癌分化。本文报告的８例肺的基底细胞样癌，显示了皮肤基底细胞癌排列的形态学特征，但较其异型性明显，癌细胞是立方形或梭形，核染色质深，胞浆极少或全无胞浆，类似于小细胞未分化癌的梭形细胞型，核分裂易见，癌巢中央见有坏死，不分泌粘液，未见嗜很颗粒，可与类癌、低分化腺癌区别。经Ｋｅｒａｔｉｎ标记为强阳性，ＣＥＡ标记仅部分癌细胞显示弱阳性。肺的基底细胞样癌恶性程度高、预后差。该肿瘤有类似于皮肤基底细胞癌的部分形态学特征，而生物学行为又为高度恶性，而称作肺的基底细胞样癌。
Basal cell carcinoma is skin, anal, canal, tongue and larynx, but it is rare inthe Lung. Basaloid carcinoma of the lung easily confused with other type of carcinoma. We have found 8 cases of basaloid carcinoma from 1978-1993, which werepreviously classified as poorly or un-differentiated or carcinoidcarcinoma.The morphological characteristics of this disease are similar to the hasal cellcarcinoma of the skin. But its cells are more anaplasia. The tumor cells are cubic orspindle, and with few or without cytoplasms. Their nuclei chromatins are dark andthe nuclear mitosis is easily seen. In the centre of the carcinoma nest can 'sully beseen. Because it can not secrete mucin and without ag. graneles, this disease can bediffentiaed from poorly differentiated adenocarcinoma and arcinoidcarc noma. Theimmunohito chemical results showed that Keretin was strong positive and CEA wasweak positive in only part of tumor cells.Basaloidcarcinoma of The lung is a highls malignant tumor and has a woreprognosis. According to the foreings reports, its 5-years survival rate was 15%.Its morphological chracteristic is similal to the hasal cell carcinoma in the skin, butbiological behavior is highly malignant.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1996年第1期14-15,共2页
Cancer Research on Prevention and Treatment
关键词
肺肿瘤
基底细胞癌
病理组织学
basaloidcarcinoma
Lung
clinicpathologic analysis.
