摘要
目的探讨血清白蛋白、D-二聚体(D-dimer)及胆碱酯酶水平,在563例多器官功能障碍综合征(MODS)患者分组的变化特点以及对预后的影响。方法入组当天检测白蛋白、胆碱酯酶与D-二聚体水平,比较563例患者预后与上述指标的关系,将MODS患者分成重度脓毒症组与非重度脓毒症组,比较两组上述指标的变化特点,观察重症感染因素对MODS的影响。结果MODS患者存活组的D-二聚体明显低于死亡组(P<0 05),白蛋白与胆碱脂酶则明显低于死亡组,重度脓毒症组的死亡率、D-二聚体水平明显高于非脓毒症组,而白蛋白明显下降,胆碱脂酶两组比较差异无显著性意义。结论白蛋白、胆碱脂酶和D-二聚体的检测对MODS患者的诊断和预后判断有指导意义,重症感染能够加重病情与预后。
OBJECTIVE To study the characteristic change and albumin（ALB）, D-dimer and acetylcholine esterase（CHE） in different groups of 563 MODS patients their significance in prognosis. METHODS We measured ALB, D-dimer and aeetylcholinesterase at the day being selected. The relationship between prognosis and the three markers was compared. The 563 patients were divided into groups with or without severe sepsis. The characteristic change in three markers were compared for inspection of the effect of severe affection on MODS. RESULTS D-Dimer in survival patients was obviously lower than that of dead ones（P〈0. 05）, their level of ALE and acetylcholinesterase was higher than that of dead ones （P〈0.05）, group with severe sepsis aggravated this change except CHE. There was no significance of CHE between the two groups. CONCLUSIONS Albumin, D-dimer and acetylcholinesterase have obvious significance to the MODS prognosis. The factor of severe inflammation can aggravate pathogenetic condition.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2006年第2期137-139,220,共4页
Chinese Journal of Nosocomiology
基金
北京市科技重大项目
京科计发[2002]641号
