摘要
目的 探讨30岁以下青年乳腺癌的临床病理学特征，以提高其诊断、治疗水平。方法 回顾性分析1996-2003年收治的53例30岁以下青年乳腺癌的发生率、组织学类型、腋窝淋巴结转移及雌激素受体表达等临床病理学特征，并分析其预后。随机挑选本院同期100例乳腺癌（年龄〉30岁）作为对照组。结果 30岁以下青年乳腺癌占同期全部乳腺癌的2．3％；53例30岁以下青年乳腺癌病例中，浸润性癌占84％；腋窝淋巴结转移率达69％；30岁以下青年组2年复发转移率为64％。30岁以下青年乳腺癌组的以上临床病理学参数与中老年乳腺癌组比较，有显著性差异（P〈0.005，P〈0．001）；但两组激素受体厦Cerb-2基因表达差别无统计学意义。结论 30岁以下青年乳腺癌有多项不同于中老年乳腺癌的临床病理学特征，顸后差。
Objective To investigate the clinical and pathological features of breast carcinoma in women aged below 30 years, and to improve the levels of diagnosis and treatment for breast carcinoma. Methods A retrospective study examining the clinical and pathological characteristics of 53 female patients （age 〈 30 years） with breast carcinoma from 1996 to 2003, including the incidence rate, histological types, axillary nodes metastasis and expression of FaR, as well as prognosis, was undertaken. We used 100 patients （age 〉 30 years）, randomly selected from our hospital during the same time, as the control. Results Incidence of breast cancer in patients aged below 30 years was 2.3% among all cases with breast cancer at the same term. Among 53 patients below 30 years, cases of 84% were infiltrating carcinoma, cases of 69% had axillary nodes metastasis, and the recurrence rate was estimated to be 64%. Most of the above clinical and pathological parameters in the young group was statistically different （ P 〈 0.005, P 〈 0.001） compared with the old group. However, the differences in expression of hormone receptor and gene Cerb - 2 had no statistical significance between two groups. Conclusion Young population （ age 〈 30 years） with breast carcinoma is found to have more aggressive biologic features than the old ones, and have poor prognosis.
出处
《美国中华临床医学杂志》
2005年第4期303-305,共3页
American Journal of Chinese Clinical Medicine
关键词
乳腺肿瘤
年龄
预后
breast neoplasms
age
prognosis
